RegulonDB RegulonDB 11.1: Gene Form
   

gcvT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gcvT gcvH yqfI GcvA GcvA Lrp CRP GcvA GcvA PurR gcvTp gcvTp

Gene      
Name: gcvT    Texpresso search in the literature
Synonym(s): ECK2900, EG11442, b2905
Genome position(nucleotides): 3049573 <-- 3050667
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.61
External database links:  
ASAP:
 ABE-0009536
CGSC:
 28667
ECHOBASE:
 EB1412
ECOLIHUB:
 gcvT
MIM:
 605899
NCBI-GENE:
 947390
OU-MICROARRAY:
 b2905
STRING:
 511145.b2905
COLOMBOS: gcvT


Product      
Name: aminomethyltransferase
Synonym(s): GcvT, T-protein
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 40.147
Isoelectric point: 5.27
Motif(s):
 
Type Positions Sequence Comment
2 -> 364 AQQTPLYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRTDAGMFDVSHMTIVDLRGSRTREFLRYLLANDVAKLTKSGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPFGIEITVRDDLSMIAVQGPNAQAKAATLFNDAQRQAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIALPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEMDETISPLAANMGWTIAWEPADRDFIGREALEVQREHGTEKLVGLVMTEKGVLRNELPVRFTDAQGNQHEGIITSGTFSPTLGYSIALARVPEGIGETAIVQIRNREMPVKVTKPVFVRNGKAVA UniProt: Aminomethyltransferase.
7 -> 254 LYEQHTLCGARMVDFHGWMMPLHYGSQIDEHHAVRTDAGMFDVSHMTIVDLRGSRTREFLRYLLANDVAKLTKSGKALYSGMLNASGGVIDDLIVYYFTEDFFRLVVNSATREKDLSWITQHAEPFGIEITVRDDLSMIAVQGPNAQAKAATLFNDAQRQAVEGMKPFFGVQAGDLFIATTGYTGEAGYEIALPNEKAADFWRALVEAGVKPCGLGARDTLRLEAGMNLYGQEMDETISPLAANMGWT
280 -> 357 KLVGLVMTEKGVLRNELPVRFTDAQGNQHEGIITSGTFSPTLGYSIALARVPEGIGETAIVQIRNREMPVKVTKPVFV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.17 - formyl-THF biosynthesis
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0005960 - glycine cleavage complex
molecular_function GO:0016740 - transferase activity
GO:0008483 - transaminase activity
GO:0004047 - aminomethyltransferase activity
biological_process GO:0006730 - one-carbon metabolic process
GO:0009257 - 10-formyltetrahydrofolate biosynthetic process
GO:0006546 - glycine catabolic process
GO:0019464 - glycine decarboxylation via glycine cleavage system
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P27248
ECOCYC:
 GCVT-MONOMER
ECOLIWIKI:
 b2905
INTERPRO:
 IPR006223
INTERPRO:
 IPR022903
INTERPRO:
 IPR013977
INTERPRO:
 IPR028896
INTERPRO:
 IPR029043
INTERPRO:
 IPR006222
INTERPRO:
 IPR027266
MODBASE:
 P27248
PANTHER:
 PTHR43757
PDB:
 3A8K
PDB:
 3A8J
PDB:
 1VLO
PDB:
 3A8I
PFAM:
 PF08669
PFAM:
 PF01571
PRIDE:
 P27248
PRODB:
 PRO_000022766
REFSEQ:
 NP_417381
SMR:
 P27248
UNIPROT:
 P27248


Operon      
Name: gcvTHP         
Operon arrangement:
Transcription unit        Promoter
gcvTHP
gcvP


Transcriptional Regulation      
Display Regulation             
Activated by: GcvA, CRP, FNR, Lrp
Repressed by: PurR, GcvA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



RegulonDB