RegulonDB RegulonDB 10.9: Gene Form
   

wecB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

wecC wecB rffG wzzE TSS_4444 TSS_4444 TSS_4443 TSS_4443 TSS_4442 TSS_4442 TSS_4441 (cluster) TSS_4441 (cluster) TSS_4440 TSS_4440 TSS_4439 TSS_4439

Gene      
Name: wecB    Texpresso search in the literature
Synonym(s): ECK3778, EG11451, b3786, mnaA, nfrC, rffE, yifF
Genome position(nucleotides): 3970133 --> 3971263 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.61
External database links:  
ASAP:
ABE-0012372
CGSC:
33915
ECHOBASE:
EB1420
ECOLIHUB:
rffE
OU-MICROARRAY:
b3786
STRING:
511145.b3786
COLOMBOS: wecB


Product      
Name: UDP-N-acetylglucosamine 2-epimerase
Synonym(s): MnaA, NfrC, RffE, WecB, YifF
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 42.245
Isoelectric point: 6.326
Motif(s):
 
Type Positions Sequence
213 -> 213 H
15 -> 15 K
95 -> 95 D
22 -> 370 ALAKDPFFEAKVCVTAQHREMLDQVLKLFSIVPDYDLNIMQPGQGLTEITCRILEGLKPILAEFKPDVVLVHGDTTTTLATSLAAFYQRIPVGHVEAGLRTGDLYSPWPEEANRTLTGHLAMYHFSPTETSRQNLLRENVADSRIFITGNTVIDALLWVRDQVMSSDKLRSELAANYPFIDPDKKMILVTGHRRESFGRGFEEICHALADIATTHQDIQIVYPVHLNPNVREPVNRILGHVKNVILIDPQEYLPFVWLMNHAWLILTDSGGIQEEAPSLGKPVLVMRDTTERPEAVTAGTVRLVGTDKQRIVEEVTRLLKDENEYQAMSRAHNPYGDGQACSRILEALK
131 -> 131 E

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.4 - enterobacterial common antigen (surface glycolipid)
  6 - cell structure --> 6.3 - surface antigens (ECA, O antigen of LPS)
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016853 - isomerase activity
GO:0008761 - UDP-N-acetylglucosamine 2-epimerase activity
GO:0042802 - identical protein binding
GO:0042803 - protein homodimerization activity
biological_process GO:0008152 - metabolic process
GO:0009246 - enterobacterial common antigen biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
UDPGLCNACEPIM-MONOMER
ECOLIWIKI:
b3786
INTERPRO:
IPR032892
INTERPRO:
IPR003331
INTERPRO:
IPR029767
MODBASE:
P27828
PANTHER:
PTHR43174
PDB:
1F6D
PDB:
1VGV
PFAM:
PF02350
PRIDE:
P27828
PRODB:
PRO_000024219
REFSEQ:
YP_026253
SMR:
P27828
UNIPROT:
P27828


Operon      
Name: rfe-wzzE-wecBC-rffGHC-wecE-wzxE-wecF-wzyE-rffM         
Operon arrangement:
Transcription unit        Promoter
rfe-wzzE-wecBC-rffGHC-wecE-wzxE-wecF-wzyE-rffM


Transcriptional Regulation      
Display Regulation             
Repressed by: NsrR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4439 3969127 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4440 3969130 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4441 (cluster) 3969176 forward For this promoter, there
Read more >
[RS-EPT-CBR] [1]
  promoter TSS_4442 3969944 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4443 3969950 forward nd [RS-EPT-CBR] [1]
  promoter TSS_4444 3971398 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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