RegulonDB RegulonDB 11.0: Gene Form
   

caiT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

caiT caiA fixA CaiF CRP CaiF CaiF CRP CaiF ArcA ArcA FNR FNR CRP ArcA ArcA  Spot 42 fixAp fixAp caiTp caiTp

Gene      
Name: caiT    Texpresso search in the literature
Synonym(s): ECK0041, EG11561, b0040, yaaP
Genome position(nucleotides): 40417 <-- 41931
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.82
External database links:  
ASAP:
ABE-0000141
CGSC:
36822
ECHOBASE:
EB1522
ECOLIHUB:
caiT
OU-MICROARRAY:
b0040
STRING:
511145.b0040
COLOMBOS: caiT


Product      
Name: L-carnitine:γ-butyrobetaine antiporter
Synonym(s): CaiT, YaaP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 56.587
Isoelectric point: 8.317
Motif(s):
 
Type Positions Sequence Comment
10 -> 30 IEPKVFFPPLIIVGILCWLTV UniProt: Helical.
14 -> 500 VFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLGNEPPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKELGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMEVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWIILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMYLPRMLFYTDPIAKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVLGLTASTWILWTVLGSNTLLLIDKNIINIPNLIEQYGVARAIIETWAALPLSTATMWGFFILCFIATVTLVNACSYTLAMSTCREVRDGEEPPLLVRIGWSILVGIIGIVLLALGGLKPIQTAIIAGGCPLFFVNIMVTLSFIKDAKQ
51 -> 71 WGWAFEWYMVVMLFGWFWLVF UniProt: Helical.
92 -> 112 IFMMFASCTSAAVLFWGSIEI UniProt: Helical.
143 -> 163 GPLPWATYSFLSVAFAYFFFV UniProt: Helical.

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015297 - antiporter activity
GO:0022857 - transmembrane transporter activity
GO:0015226 - carnitine transmembrane transporter activity
GO:0044667 - (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
biological_process GO:0009437 - carnitine metabolic process
GO:0055085 - transmembrane transport
GO:0015879 - carnitine transport
GO:0071705 - nitrogen compound transport
GO:1900749 - (R)-carnitine transport
GO:1900751 - 4-(trimethylammonio)butanoate transport
GO:1902270 - (R)-carnitine transmembrane transport
GO:1902603 - carnitine transmembrane transport
External database links:  
ALPHAFOLD:
P31553
DIP:
DIP-9247N
ECOCYC:
CAIT-MONOMER
ECOLIWIKI:
b0040
INTERPRO:
IPR018093
INTERPRO:
IPR023449
INTERPRO:
IPR000060
PANTHER:
PTHR30047
PDB:
2WSX
PDB:
3HFX
PFAM:
PF02028
PRIDE:
P31553
PRODB:
PRO_000022246
PROSITE:
PS01303
REFSEQ:
NP_414582
SMR:
P31553
UNIPROT:
P31553


Operon      
Name: caiTABCDE         
Operon arrangement:
Transcription unit        Promoter
caiTABCDE
caiCDE


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, FNR, ArcA, CaiF
Repressed by: H-NS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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