RegulonDB RegulonDB 10.9: Gene Form
   

bacA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

cca bacA folB CpxR plsYp5 plsYp5 bacAp bacAp

Gene      
Name: bacA    Texpresso search in the literature
Synonym(s): ECK3047, EG11665, b3057, uppP
Genome position(nucleotides): 3203310 <-- 3204131 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.43
External database links:  
ASAP:
ABE-0010034
CGSC:
29739
ECHOBASE:
EB1616
ECOLIHUB:
bacA
OU-MICROARRAY:
b3057
STRING:
511145.b3057
COLOMBOS: bacA


Product      
Name: undecaprenyl pyrophosphate phosphatase
Synonym(s): BacA, UppP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 29.759
Isoelectric point: 8.478
Motif(s):
 
Type Positions Sequence
24 -> 49 PVSSTGHMIIVGHLLGFEGDTAKTFE
175 -> 175 S
190 -> 210 YAASEFSFLLAVPMMMGATAL
26 -> 26 S
222 -> 242 GDIPMFAVGFITAFVVALIAI

 

Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016787 - hydrolase activity
GO:0016462 - pyrophosphatase activity
GO:0050380 - undecaprenyl-diphosphatase activity
biological_process GO:0000270 - peptidoglycan metabolic process
GO:0009252 - peptidoglycan biosynthetic process
GO:0016311 - dephosphorylation
GO:0046677 - response to antibiotic
GO:0008360 - regulation of cell shape
GO:0071555 - cell wall organization
Note(s): Note(s): ...[more].
Reference(s): [1] Bickford JS., et al., 2013
[2] Ovchinnikov S., et al., 2015
[3] Workman SD., et al., 2018
External database links:  
DIP:
DIP-48044N
ECOCYC:
EG11665-MONOMER
ECOLIWIKI:
b3057
INTERPRO:
IPR003824
PANTHER:
PTHR30622
PDB:
6CB2
PFAM:
PF02673
PRIDE:
P60932
PRODB:
PRO_000024185
REFSEQ:
NP_417529
SMR:
P60932
UNIPROT:
P60932


Operon      
Name: bacA         
Operon arrangement:
Transcription unit        Promoter
bacA


Transcriptional Regulation      
Display Regulation             
Activated by: CpxR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter plsYp5 3204533 forward Similarity to the consensus
Read more >
[ICWHO] [4]


Evidence    

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Bickford JS., Nick HS., 2013, Conservation of the PTEN catalytic motif in the bacterial undecaprenyl pyrophosphate phosphatase, BacA/UppP., Microbiology 159(Pt 12):2444-55

 [2] Ovchinnikov S., Kinch L., Park H., Liao Y., Pei J., Kim DE., Kamisetty H., Grishin NV., Baker D., 2015, Large-scale determination of previously unsolved protein structures using evolutionary information., Elife 4:e09248

 [3] Workman SD., Worrall LJ., Strynadka NCJ., 2018, Crystal structure of an intramembranal phosphatase central to bacterial cell-wall peptidoglycan biosynthesis and lipid recycling., Nat Commun 9(1):1159

 [4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


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