RegulonDB RegulonDB 10.9: Gene Form
   

emrD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

emrD yidF ysdE yidG terminator emrDp emrDp

Gene      
Name: emrD    Texpresso search in the literature
Synonym(s): ECK3664, EG11693, b3673, yicQ
Genome position(nucleotides): 3853922 --> 3855106 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
57.13
External database links:  
ASAP:
ABE-0012011
CGSC:
36938
ECHOBASE:
EB1644
ECOLIHUB:
emrD
OU-MICROARRAY:
b3673
STRING:
511145.b3673
COLOMBOS: emrD


Product      
Name: multidrug efflux pump EmrD
Synonym(s): EmrD, YicQ
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 42.216
Isoelectric point: 9.692
Motif(s):
 
Type Positions Sequence
135 -> 155 SLLNMGILVSPLLAPLIGGLL
277 -> 297 SVICCLLAGLLMWIPDWFGVM
299 -> 319 VWTLLVPAALFFFGAGMLFPL
330 -> 350 FLAGTAGALVGGLQNIGSGVL
96 -> 116 LTVLIAASAMQGMGTGVGGVM

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
GO:0015299 - solute:proton antiporter activity
GO:0042910 - xenobiotic transmembrane transporter activity
biological_process GO:1990961 - xenobiotic detoxification by transmembrane export across the plasma membrane
GO:0006855 - drug transmembrane transport
GO:0055085 - transmembrane transport
GO:0042908 - xenobiotic transport
Note(s): Note(s): ...[more].
Reference(s): [1] Cymer F., et al., 2013
[2] Lewis K., et al., 1994
[3] Steed PR., et al., 2013
[4] Yu L., et al., 2020
External database links:  
ECOCYC:
EMRD-MONOMER
ECOLIWIKI:
b3673
INTERPRO:
IPR036259
INTERPRO:
IPR004734
INTERPRO:
IPR011701
INTERPRO:
IPR020846
MODBASE:
P31442
PDB:
2GFP
PFAM:
PF07690
PRIDE:
P31442
PRODB:
PRO_000022511
PROSITE:
PS50850
REFSEQ:
NP_418129
SMR:
P31442
UNIPROT:
P31442


Operon      
Name: emrD         
Operon arrangement:
Transcription unit        Promoter
emrD


Transcriptional Regulation      
Display Regulation             
Activated by: Fis


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Cymer F., von Heijne G., 2013, Cotranslational folding of membrane proteins probed by arrest-peptide-mediated force measurements., Proc Natl Acad Sci U S A 110(36):14640-5

 [2] Lewis K., Naroditskaya V., Ferrante A., Fokina I., 1994, Bacterial resistance to uncouplers., J Bioenerg Biomembr 26(6):639-46

 [3] Steed PR., Zou P., Trone KE., Mchaourab HS., 2013, Structure and pH-induced structural rearrangements of the putative multidrug efflux pump EmrD in liposomes probed by site-directed spin labeling., Biochemistry 52(45):7964-74

 [4] Yu L., Li W., Xue M., Li J., Chen X., Ni J., Shang F., Xue T., 2020, Regulatory Role of the Two-Component System BasSR in the Expression of the EmrD Multidrug Efflux in Escherichia coli., Microb Drug Resist


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