RegulonDB

Gene
Name:	envR
Synonym(s):	ECK3251, EG11741, acrS, b3264, yhdK
Genome position(nucleotides):	3412803 <-- 3413465 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	44.19
External database links:

ASAP:	ABE-0010712
ECHOBASE:	EB1692
ECOLIHUB:	envR
OU-MICROARRAY:	b3264
STRING:	511145.b3264
COLOMBOS:	envR

Product

Name:

DNA-binding transcriptional repressor EnvR

Synonym(s):

AcrS, EnvR, YhdK

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

TetR/AcrR

Cellular location:

cytosol

Molecular weight:

25.198

Isoelectric point:

5.944

Motif(s):

Type	Positions	Sequence
	16 -> 62	LIETAIAQFAQHGVSKTTLNDIADAANVTRGAIYWHFENKTQLFNEM
	33 -> 52	TLNDIADAANVTRGAIYWHF
	10 -> 70	LKTRQELIETAIAQFAQHGVSKTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQQPSLR
	84 -> 202	DPFQQLREKLIVGLQYIAKIPRQQALLKILYHKCEFNDEMLAEGVIREKMGFNPQTLREVLQACQQQGCVANNLDLDVVMIIIDGAFSGIVQNWLMNMAGYDLYKQAPALVDNVLRMFM

Classification:

Multifun Terms (GenProtEC)
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
		5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity
	biological_process	GO:0042493 - response to drug GO:0045892 - negative regulation of transcription, DNA-templated

Note(s):

Note(s): ...[more].

Evidence:

[APPH] Assay of protein purified to homogeneity
[HIFS] Human inference of function from sequence

Reference(s):

[1] Hirakawa H., et al., 2008
[2] Pan W., et al., 1994
[3] Yang K., et al., 1995

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PFAM:

PRIDE:

PRINTS:

PROSITE:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	envRp11	3413487	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 4.476. P-value: 1.044e-5 Read more >	[ICWHO]	[4]
promoter	envRp13	3413601	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 4.72. P-value: 2.347e-5 Read more >	[ICWHO]	[4]
promoter	envRp12	3413602	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.503. P-value: 4.690e-6 Read more >	[ICWHO]	[4]
promoter	envRp9	3413607	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.703. P-value: 9.636e-6 Read more >	[ICWHO]	[4]
promoter	envRp15	3413621	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 5.426. P-value: 2.983e-5 Read more >	[ICWHO]	[4]
promoter	envRp14	3413633	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.924. P-value: 1.743e-6 Read more >	[ICWHO]	[4]

Reference(s)
[1] Hirakawa H., Takumi-Kobayashi A., Theisen U., Hirata T., Nishino K., Yamaguchi A., 2008, AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli., J Bacteriol 190(18):6276-9
[2] Pan W., Spratt BG., 1994, Regulation of the permeability of the gonococcal cell envelope by the mtr system., Mol Microbiol 11(4):769-75
[3] Yang K., Han L., Vining LC., 1995, Regulation of jadomycin B production in Streptomyces venezuelae ISP5230: involvement of a repressor gene, jadR2., J Bacteriol 177(21):6111-7
[4] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78