RegulonDB RegulonDB 11.0: Gene Form
   

gmd gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gmd fcl wcaF

Gene      
Name: gmd    Texpresso search in the literature
Synonym(s): ECK2047, EG11787, b2053, yefA, yefN
Genome position(nucleotides): 2127193 <-- 2128314
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.81
External database links:  
ASAP:
 ABE-0006803
ECHOBASE:
 EB1735
ECOLIHUB:
 gmd
OU-MICROARRAY:
 b2053
STRING:
 511145.b2053
COLOMBOS: gmd


Product      
Name: GDP-mannose 4,6-dehydratase
Synonym(s): Gmd, YefA, YefN
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 42.047
Isoelectric point: 6.097
Motif(s):
 
Type Positions Sequence Comment
6 -> 346 LITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLHYGDLSDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAIRFLGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRAIANIAQGLESCLYLGNMDSLRDWGHAKDYVKMQWMMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRFEGTGVEEKGIVVSVTGHDAPGVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPEITLREMVSEM
9 -> 14 GVTGQD UniProt: NADP.
64 -> 65 DL UniProt: NADP.
86 -> 90 LGAMS UniProt: NADP.
133 -> 133 T UniProt: Strongly reduces activity..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.7 - nicotinamide adenine dinucleotide
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.2 - colanic acid (M antigen)
  5 - cell processes --> 5.5 - adaptations --> 5.5.5 - dessication
  6 - cell structure --> 6.3 - surface antigens (ECA, O antigen of LPS)
  6 - cell structure --> 6.7 - capsule (M and K antigens)
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016829 - lyase activity
GO:0008446 - GDP-mannose 4,6-dehydratase activity
GO:0042803 - protein homodimerization activity
GO:0070401 - NADP+ binding
biological_process GO:0009242 - colanic acid biosynthetic process
GO:0019673 - GDP-mannose metabolic process
GO:0042351 - 'de novo' GDP-L-fucose biosynthetic process
External database links:  
ALPHAFOLD:
 P0AC88
DIP:
 DIP-48216N
ECOCYC:
 GDPMANDEHYDRA-MONOMER
ECOLIWIKI:
 b2053
INTERPRO:
 IPR016040
INTERPRO:
 IPR036291
INTERPRO:
 IPR006368
MODBASE:
 P0AC88
PANTHER:
 PTHR43715
PDB:
 1DB3
PFAM:
 PF16363
PRIDE:
 P0AC88
PRODB:
 PRO_000022819
REFSEQ:
 NP_416557
SMR:
 P0AC88
UNIPROT:
 P0AC88


Operon      
Name: wcaCDEF-gmd-fcl-gmm-wcaI-cpsBG-wcaJ-wzxC         
Operon arrangement:
Transcription unit        Promoter
wcaCDEF-gmd-fcl-gmm-wcaI-cpsBG-wcaJ-wzxC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



RegulonDB