RegulonDB RegulonDB 11.1: Gene Form
   

gcvP gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gcvP ygfF gcvH TSS_3176 TSS_3176

Gene      
Name: gcvP    Texpresso search in the literature
Synonym(s): ECK2898, EG11810, b2903
Genome position(nucleotides): 3046168 <-- 3049041
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.95
External database links:  
ASAP:
 ABE-0009531
CGSC:
 28661
ECHOBASE:
 EB1758
ECOLIHUB:
 gcvP
MIM:
 605899
NCBI-GENE:
 947394
OU-MICROARRAY:
 b2903
STRING:
 511145.b2903
COLOMBOS: gcvP


Product      
Name: glycine decarboxylase
Synonym(s): GcvP, P-protein
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 104.376
Isoelectric point: 5.893
Motif(s):
 
Type Positions Sequence Comment
2 -> 957 TQTLSQLENSGAFIERHIGPDAAQQQEMLNAVGAQSLNALTGQIVPKDIQLATPPQVGAPATEYAALAELKAIASRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFEVIVDDAQKVLDHQDVFGVLLQQVGTTGEIHDYTALISELKSRKIVVSVAADIMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEYKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPVGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAGVLTRAEAAEINLRSDILNAVGITLDETTTRENVMQLFNVLLGDNHGLDIDTLDKDVAHDSRSIQPAMLRDDEILTHPVFNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYQQMIAQLADWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLTDLRAKAEQAGDNLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSVVQIEGMLTRQGAVSAAPFGSASILPISWMYIRMMGAEGLKKASQVAILNANYIASRLQDAFPVLYTGRDGRVAHECILDIRPLKEETGISELDIAKRLIDYGFHAPTMSFPVAGTLMVEPTESESKVELDRFIDAMLAIRAEIDQVKAGVWPLEDNPLVNAPHIQSELVAEWAHPYSREVAVFPAGVADKYWPTVKRLDDVYGDRNLFCSCVPISEYQ UniProt: Glycine dehydrogenase (decarboxylating).
16 -> 440 ERHIGPDAAQQQEMLNAVGAQSLNALTGQIVPKDIQLATPPQVGAPATEYAALAELKAIASRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVASDVHPQTLDVVRTRAETFGFEVIVDDAQKVLDHQDVFGVLLQQVGTTGEIHDYTALISELKSRKIVVSVAADIMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEYKRSMPGRIIGVSKDAAGNTALRMAMQTREQHIRREKANSNICTSQVLLANIASLYAVYHGPVGLKRIANRIHRLTDILAAGLQQKGLKLRHAHYFDTLCVEVADKAGVLTRAEAAEINLRSDILNAVGITLDETTTRENVMQLFNVL
479 -> 739 FNRYHSETEMMRYMHSLERKDLALNQAMIPLGSCTMKLNAAAEMIPITWPEFAELHPFCPPEQAEGYQQMIAQLADWLVKLTGYDAVCMQPNSGAQGEYAGLLAIRHYHESRNEGHRDICLIPASAHGTNPASAHMAGMQVVVVACDKNGNIDLTDLRAKAEQAGDNLSCIMVTYPSTHGVYEETIREVCEVVHQFGGQVYLDGANMNAQVGITSPGFIGADVSHLNLHKTFCIPHGGGGPGMGPIGVKAHLAPFVPGHSV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.17 - formyl-THF biosynthesis
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0005960 - glycine cleavage complex
molecular_function GO:0003824 - catalytic activity
GO:0016491 - oxidoreductase activity
GO:0004375 - glycine dehydrogenase (decarboxylating) activity
GO:0030170 - pyridoxal phosphate binding
GO:0042802 - identical protein binding
GO:0016594 - glycine binding
biological_process GO:0006544 - glycine metabolic process
GO:0006730 - one-carbon metabolic process
GO:0006546 - glycine catabolic process
GO:0019464 - glycine decarboxylation via glycine cleavage system
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P33195
DIP:
 DIP-9753N
ECOCYC:
 GCVP-MONOMER
ECOLIWIKI:
 b2903
INTERPRO:
 IPR015424
INTERPRO:
 IPR003437
INTERPRO:
 IPR015421
INTERPRO:
 IPR015422
INTERPRO:
 IPR020581
MODBASE:
 P33195
PANTHER:
 PTHR11773
PFAM:
 PF02347
PRIDE:
 P33195
PRODB:
 PRO_000022764
REFSEQ:
 NP_417379
SMR:
 P33195
UNIPROT:
 P33195


Operon      
Name: gcvTHP         
Operon arrangement:
Transcription unit        Promoter
gcvTHP
gcvP


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, GcvA, FNR, Lrp
Repressed by: PurR, GcvA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3176 3048166 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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