RegulonDB RegulonDB 10.9: Gene Form
   

hemN gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hemN yihI yshB TSS_4545 TSS_4545 hemNp hemNp

Gene      
Name: hemN    Texpresso search in the literature
Synonym(s): ECK3860, EG11836, b3867, yihJ
Genome position(nucleotides): 4052045 --> 4053418 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.13
External database links:  
ASAP:
ABE-0012629
ECHOBASE:
EB1782
ECOLIHUB:
hemN
OU-MICROARRAY:
b3867
STRING:
511145.b3867
COLOMBOS: hemN


Product      
Name: coproporphyrinogen III dehydrogenase
Synonym(s): HemN, YihJ
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 52.729
Isoelectric point: 5.957
Motif(s):
 
Type Positions Sequence
56 -> 56 Y
57 -> 227 VHIPFCHKLCYFCGCNKIVTRQQHKADQYLDALEQEIVHRAPLFAGRHVSQLHWGGGTPTYLNKAQISRLMKLLRENFQFNADAEISIEVDPREIELDVLDHLRAEGFNRLSMGVQDFNKEVQRLVNREQDEEFIFALLNHAREIGFTSTNIDLIYGLPKQTPESFAFTLK
66 -> 66 C
68 -> 70 FCG
71 -> 71 C

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.3 - cofactors, small molecule carriers --> 1.5.3.12 - heme, porphyrine
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0051536 - iron-sulfur cluster binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0004109 - coproporphyrinogen oxidase activity
GO:0051989 - coproporphyrinogen dehydrogenase activity
biological_process GO:0006779 - porphyrin-containing compound biosynthetic process
GO:0055114 - oxidation-reduction process
GO:0019353 - protoporphyrinogen IX biosynthetic process from glutamate
GO:0006782 - protoporphyrinogen IX biosynthetic process
Note(s): Note(s): ...[more].
External database links:  
DIP:
DIP-9887N
ECOCYC:
HEMN-MONOMER
ECOLIWIKI:
b3867
INTERPRO:
IPR004558
INTERPRO:
IPR023404
INTERPRO:
IPR034505
INTERPRO:
IPR006638
INTERPRO:
IPR007197
INTERPRO:
IPR010723
MODBASE:
P32131
PANTHER:
PTHR13932
PDB:
1OLT
PFAM:
PF06969
PFAM:
PF04055
PRIDE:
P32131
PRODB:
PRO_000022879
PROSITE:
PS51918
REFSEQ:
NP_418303
SMART:
SM00729
SMR:
P32131
UNIPROT:
P32131


Operon      
Name: hemN         
Operon arrangement:
Transcription unit        Promoter
hemN


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4545 4052097 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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