RegulonDB RegulonDB 10.9: Gene Form
   

fieF gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pfkA fieF cpxQ Cra terminator TSS_4610 TSS_4610 TSS_4609 TSS_4609 TSS_4608 (cluster) TSS_4608 (cluster) TSS_4607 TSS_4607 TSS_4606 (cluster) TSS_4606 (cluster) TSS_4605 (cluster) TSS_4605 (cluster) TSS_4604 (cluster) TSS_4604 (cluster) pfkAp1 pfkAp1 TSS_4603 (cluster) TSS_4603 (cluster) pfkAp2 pfkAp2 TSS_4601 (cluster) TSS_4601 (cluster) TSS_4600 (cluster) TSS_4600 (cluster) fieFp4 fieFp4 fieFp3 fieFp3

Gene      
Name: fieF    Texpresso search in the literature
Synonym(s): ECK3907, EG11873, b3915, yiiP
Genome position(nucleotides): 4106469 --> 4107371 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.16
External database links:  
ASAP:
ABE-0012786
ECHOBASE:
EB1819
ECOLIHUB:
fieF
OU-MICROARRAY:
b3915
STRING:
511145.b3915
COLOMBOS: fieF


Product      
Name: Zn2+/Fe2+/Cd2+ exporter
Synonym(s): FieF, YiiP
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 32.927
Isoelectric point: 6.605
Motif(s):
 
Type Positions Sequence
10 -> 27 SRAAIAATAMASLLLLIK
127 -> 141 CTIILVSFQRWVVRR
146 -> 159 AVRADMLHYQSDVM
78 -> 99 AESLAALAQSMFISGSALFLFL
80 -> 102 SLAALAQSMFISGSALFLFLTGI

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0008324 - cation transmembrane transporter activity
GO:0015086 - cadmium ion transmembrane transporter activity
GO:0015093 - ferrous iron transmembrane transporter activity
GO:0046873 - metal ion transmembrane transporter activity
GO:0015341 - zinc efflux active transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
GO:0042802 - identical protein binding
biological_process GO:0006811 - ion transport
GO:0006812 - cation transport
GO:0006826 - iron ion transport
GO:0006829 - zinc ion transport
GO:0006876 - cellular cadmium ion homeostasis
GO:0006879 - cellular iron ion homeostasis
GO:0006882 - cellular zinc ion homeostasis
GO:0015691 - cadmium ion transport
GO:0055072 - iron ion homeostasis
GO:0055085 - transmembrane transport
GO:0034755 - iron ion transmembrane transport
GO:0071577 - zinc ion transmembrane transport
GO:0070574 - cadmium ion transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Nies DH. 2007
External database links:  
DIP:
DIP-48564N
ECOCYC:
YIIP-MONOMER
ECOLIWIKI:
b3915
INTERPRO:
IPR036837
INTERPRO:
IPR002524
INTERPRO:
IPR023783
INTERPRO:
IPR027469
INTERPRO:
IPR027470
PDB:
3H90
PDB:
2qfi
PFAM:
PF01545
PFAM:
PF16916
PRIDE:
P69380
PRODB:
PRO_000022615
REFSEQ:
NP_418350
SMR:
P69380
UNIPROT:
P69380


Operon      
Name: fieF         
Operon arrangement:
Transcription unit        Promoter
fieF


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter fieFp3 4106432 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter fieFp4 4106449 forward Similarity to the consensus
Read more >
[ICWHO], [RS-EPT-CBR] [2], [3]
  promoter TSS_4600 (cluster) 4107207 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4601 (cluster) 4107419 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4603 (cluster) 4107519 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4604 (cluster) 4107525 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4605 (cluster) 4107530 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4606 (cluster) 4107538 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4607 4107556 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4608 (cluster) 4107822 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_4609 4107877 forward nd [RS-EPT-CBR] [3]
  promoter TSS_4610 4108126 forward nd [RS-EPT-CBR] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Nies DH., 2007, Biochemistry. How cells control zinc homeostasis., Science 317(5845):1695-6

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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