RegulonDB

Gene
Name:	dctR
Synonym(s):	ECK3491, EG11889, b3507, yhiF
Genome position(nucleotides):	3654683 --> 3655213
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	39.74
External database links:

ASAP:	ABE-0011454
ECHOBASE:	EB1835
ECOLIHUB:	dctR
OU-MICROARRAY:	b3507
STRING:	511145.b3507
COLOMBOS:	dctR

Gene

Name:

dctR

Synonym(s):

ECK3491, EG11889, b3507, yhiF

Genome position(nucleotides):

3654683 --> 3655213

Strand:

forward

Sequence:

Get nucleotide sequence FastaFormat

GC content %:

39.74

External database links:

ASAP:

ECHOBASE:

ECOLIHUB:

OU-MICROARRAY:

STRING:

COLOMBOS:

Product

Name:

putative DNA-binding transcriptional regulator DctR

Synonym(s):

DctR, YhiF

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

20.408

Isoelectric point:

8.96

Motif(s):

Type	Positions	Sequence	Comment
	109 -> 174	VPEAAVSLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNLKRINELVRHQHIDY	UniProt: HTH luxR-type.
	115 -> 169	SLSRKQHQVLSCIANQMTTEDILEKLKISLKTFYCHKHNIMMILNLKRINELVRH
	133 -> 152	TEDILEKLKISLKTFYCHKH	UniProt: H-T-H motif.
	163 -> 176	INELVRHQHIDYLV	UniProt: In Ref. 1; AAA60371..

Classification:

Multifun Terms (GenProtEC)
		3 - regulation --> 3.1 - type of regulation --> 3.1.4 - unknown
		5 - cell processes --> 5.5 - adaptations --> 5.5.4 - pH
Gene Ontology Terms (GO)
	cellular_component	GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0005515 - protein binding
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0043471 - regulation of cellular carbohydrate catabolic process GO:1990451 - cellular stress response to acidic pH

Note(s):

Note(s): ...[more].

Evidence:

[COMP-AINF-FN-FROM-SEQ] Automated inference of function from sequence
[COMP-HINF-FN-FROM-SEQ] Human inference of function from sequence
[EXP-IGI] Inferred from genetic interaction
[EXP-IMP] Inferred from mutant phenotype

Reference(s):

[1] Boogerd FC., et al., 1998
[2] Mates AK., et al., 2007
[3] Perez-Rueda E., et al., 2004
[4] Segev E., et al., 2018

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PFAM:

PRIDE:

PRODB:

PROSITE:

REFSEQ:

SMART:

SMR:

UNIPROT:

Transcriptional Regulation
	Display Regulation
Activated by:	GadX, GadE-RcsB, YdeO
Repressed by:	MarA, H-NS, GadW

Transcriptional Regulation

Display Regulation

Activated by:

GadX, GadE-RcsB, YdeO

Repressed by:

MarA, H-NS, GadW

Reference(s)
[1] Boogerd FC., Boe L., Michelsen O., Jensen PR., 1998, atp Mutants of Escherichia coli fail to grow on succinate due to a transport deficiency., J Bacteriol 180(22):5855-9
[2] Mates AK., Sayed AK., Foster JW., 2007, Products of the Escherichia coli acid fitness island attenuate metabolite stress at extremely low pH and mediate a cell density-dependent acid resistance., J Bacteriol 189(7):2759-68
[3] Perez-Rueda E., Collado-Vides J., Segovia L., 2004, Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea., Comput Biol Chem 28(5-6):341-50
[4] Segev E., Pasternak Z., Ben Sasson T., Jurkevitch E., Gonen M., 2018, Automatic identification of optimal marker genes for phenotypic and taxonomic groups of microorganisms., PLoS One 13(5):e0195537

Reference(s)

[1] Boogerd FC., Boe L., Michelsen O., Jensen PR., 1998, atp Mutants of Escherichia coli fail to grow on succinate due to a transport deficiency., J Bacteriol 180(22):5855-9

[2] Mates AK., Sayed AK., Foster JW., 2007, Products of the Escherichia coli acid fitness island attenuate metabolite stress at extremely low pH and mediate a cell density-dependent acid resistance., J Bacteriol 189(7):2759-68

[3] Perez-Rueda E., Collado-Vides J., Segovia L., 2004, Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea., Comput Biol Chem 28(5-6):341-50

[4] Segev E., Pasternak Z., Ben Sasson T., Jurkevitch E., Gonen M., 2018, Automatic identification of optimal marker genes for phenotypic and taxonomic groups of microorganisms., PLoS One 13(5):e0195537