RegulonDB RegulonDB 10.8: Gene Form
   

gldA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gldA fsaB yijF TSS_4653 TSS_4653 TSS_4652 TSS_4652 gldAp4 gldAp4 yijFp5 yijFp5

Gene      
Name: gldA    Texpresso search in the literature
Synonym(s): ECK3937, EG11904, b3945
Genome position(nucleotides): 4137932 <-- 4139035 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
54.71
External database links:  
ASAP:
ABE-0012912
CGSC:
34147
ECHOBASE:
EB1849
ENTREZ:
U00006
OU-MICROARRAY:
b3945
PortEco:
gldA
STRING:
511145.b3945
COLOMBOS: gldA


Product      
Name: L-1,2-propanediol dehydrogenase / glycerol dehydrogenase
Synonym(s): GldA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 38.712
Isoelectric point: 4.52
Motif(s):
 
Type Positions Sequence
94 -> 98 GKTLD
116 -> 119 TIAS
8 -> 348 PGKYIQGADVINRLGEYLKPLAERWLVVGDKFVLGFAQSTVEKSFKDAGLVVEIAPFGGECSQNEIDRLRGIAETAQCGAILGIGGGKTLDTAKALAHFMGVPVAIAPTIASTDAPCSALSVIYTDEGEFDRYLLLPNNPNMVIVDTKIVAGAPARLLAAGIGDALATWFEARACSRSGATTMAGGKCTQAALALAELCYNTLLEEGEKAMLAAEQHVVTPALERVIEANTYLSGVGFESGGLAAAHAVHNGLTAIPDAHHYYHGEKVAFGTLTQLVLENAPVEEIETVAALSHAVGLPITLAQLDIKEDVPAKMRIVAEAACAEGETIHNMPGGATPDQV

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.6 - misc. glycerol metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0032991 - protein-containing complex
molecular_function GO:0046872 - metal ion binding
GO:0016491 - oxidoreductase activity
GO:0016614 - oxidoreductase activity, acting on CH-OH group of donors
GO:0008270 - zinc ion binding
GO:0008888 - glycerol dehydrogenase [NAD+] activity
GO:0019147 - (R)-aminopropanol dehydrogenase activity
GO:0042802 - identical protein binding
biological_process GO:0006071 - glycerol metabolic process
GO:0051596 - methylglyoxal catabolic process
GO:0055114 - oxidation-reduction process
GO:0019588 - anaerobic glycerol catabolic process
GO:0051289 - protein homotetramerization
External database links:  
DIP:
DIP-47916N
ECOCYC:
GLYCDEH-MONOMER
ECOLIWIKI:
b3945
INTERPRO:
IPR016205
INTERPRO:
IPR001670
INTERPRO:
IPR018211
MODBASE:
P0A9S5
PANTHER:
PTHR43616
PDB:
5ZXL
PFAM:
PF00465
PRIDE:
P0A9S5
PRODB:
PRO_000022774
PROSITE:
PS00060
PROSITE:
PS00913
REFSEQ:
NP_418380
SMR:
P0A9S5
SWISSMODEL:
P0A9S5
UNIPROT:
P0A9S5


Operon      
Name: ptsA-fsaB-gldA         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter yijFp5 4137864 reverse Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter gldAp4 4139046 reverse Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_4652 4139090 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_4653 4139097 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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