RegulonDB RegulonDB 11.0: Gene Form
   

setB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

setB fruB yeiP yeiW CRP Cra Cra terminator anti-terminator anti-anti-terminator terminator TSS_2470 TSS_2470 TSS_2469 TSS_2469 yeiWp6 yeiWp6 TSS_2468 TSS_2468 yeiPp yeiPp TSS_2467 (cluster) TSS_2467 (cluster) yeiWp7 yeiWp7 yeiWp yeiWp TSS_2466 TSS_2466 setBp3 setBp3 setBp2 setBp2 fruBp fruBp TSS_2465 TSS_2465 TSS_2464 TSS_2464

Gene      
Name: setB    Texpresso search in the literature
Synonym(s): ECK2163, EG12034, b2170, yeiO
Genome position(nucleotides): 2263863 --> 2265044
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.05
External database links:  
ASAP:
 ABE-0007184
ECHOBASE:
 EB1969
ECOLIHUB:
 setB
OU-MICROARRAY:
 b2170
STRING:
 511145.b2170
COLOMBOS: setB


Product      
Name: sugar exporter SetB
Synonym(s): SetB, SetB MFS transporter, YeiO
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 42.746
Isoelectric point: 9.589
Motif(s):
 
Type Positions Sequence Comment
13 -> 33 FDLTSTAFLIVAFLTGIAGAL UniProt: Helical.
21 -> 356 LIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMRKELPLATGTIEAPRRNRRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIA
51 -> 71 AMVGFFFTGSAVIGILVSQFL UniProt: Helical.
82 -> 102 KSLIVFCCLLGVLACTLFAWN UniProt: Helical.
106 -> 126 FVLLFVGVFLSSFGSTANPQM UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005351 - carbohydrate:proton symporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:0008643 - carbohydrate transport
GO:0007059 - chromosome segregation
GO:0055085 - transmembrane transport
GO:0015767 - lactose transport
GO:0034219 - carbohydrate transmembrane transport
GO:1902600 - proton transmembrane transport
GO:0036448 - cellular response to glucose-phosphate stress
GO:1904659 - glucose transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P33026
ECOCYC:
 B2170-MONOMER
ECOLIWIKI:
 b2170
INTERPRO:
 IPR020846
INTERPRO:
 IPR036259
INTERPRO:
 IPR011701
INTERPRO:
 IPR004750
MODBASE:
 P33026
PANTHER:
 PTHR23535:SF2
PFAM:
 PF07690
PRIDE:
 P33026
PRODB:
 PRO_000023937
PROSITE:
 PS50850
REFSEQ:
 NP_416675
UNIPROT:
 P33026


Operon      
Name: setB         
Operon arrangement:
Transcription unit        Promoter
setB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_2464 2262611 reverse nd [RS-EPT-CBR] [1]
  promoter TSS_2465 2263594 reverse nd [RS-EPT-CBR] [1]
  promoter setBp2 2263713 forward nd [ICWHO] [2]
  promoter setBp3 2263836 forward nd [ICWHO] [2]
  promoter TSS_2466 2263839 forward nd [RS-EPT-CBR] [1]
  promoter yeiWp7 2265413 reverse nd [ICWHO] [2]
  promoter TSS_2467 (cluster) 2265414 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2468 2265420 forward nd [RS-EPT-CBR] [1]
  promoter yeiWp6 2265420 reverse nd [ICWHO] [2]
  promoter TSS_2469 2265428 forward nd [RS-EPT-CBR] [1]
  promoter TSS_2470 2265434 forward nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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