RegulonDB RegulonDB 11.1: Gene Form
   

ccmC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ccmC ccmB ccmE ccmD ccmF ccmA

Gene      
Name: ccmC    Texpresso search in the literature
Synonym(s): ECK2191, EG12057, b2199, yejT, yejU
Genome position(nucleotides): 2295583 <-- 2296320
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.28
External database links:  
ASAP:
 ABE-0007275
CGSC:
 36581
ECHOBASE:
 EB1987
ECOLIHUB:
 ccmC
OU-MICROARRAY:
 b2199
STRING:
 511145.b2199
COLOMBOS: ccmC


Product      
Name: cytochrome c maturation protein C
Synonym(s): CcmC, YejT, YejU, heme trafficking system protein C
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 27.885
Isoelectric point: 10.935
Motif(s):
 
Type Positions Sequence Comment
9 -> 184 AIPPRLYQICGWFIPWLAIASVVVLTVGWIWGFGFAPADYQQGNSYRIIYLHVPAAIWSMGIYASMAVAAFIGLVWQMKMANLAVAAMAPIGAVFTFIALVTGSAWGKPMWGTWWVWDARLTSELVLLFLYVGVIALWHAFDDRRLAGRAAGILVLIGVVNLPIIHYSVEWWNTLH
17 -> 36 ICGWFIPWLAIASVVVLTVG
21 -> 41 FIPWLAIASVVVLTVGWIWGF UniProt: Helical.
63 -> 82 AAIWSMGIYASMAVAAFIGL
64 -> 84 AIWSMGIYASMAVAAFIGLVW UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.15 - large molecule carriers --> 1.6.15.1 - cytochromes
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
molecular_function GO:0005515 - protein binding
GO:0015232 - heme transmembrane transporter activity
GO:0020037 - heme binding
biological_process GO:1903607 - cytochrome c biosynthetic process
GO:1904334 - heme import across plasma membrane
GO:0017004 - cytochrome complex assembly
GO:0015886 - heme transport
GO:0017003 - protein-heme linkage
Note(s): Note(s): ...[more].
Reference(s): [1] Richard-Fogal C., et al., 2010
External database links:  
ALPHAFOLD:
 P0ABM1
ECOCYC:
 CCMC-MONOMER
ECOLIWIKI:
 b2199
INTERPRO:
 IPR002541
INTERPRO:
 IPR003557
MINT:
 P0ABM1
PFAM:
 PF01578
PRIDE:
 P0ABM1
PRINTS:
 PR01386
PRODB:
 PRO_000022259
REFSEQ:
 NP_416703
UNIPROT:
 P0ABM1


Operon      
Name: napFDAGHBC-ccmABCDEFGH         
Operon arrangement:
Transcription unit        Promoter
napFDAGHBC-ccmABCDEFGH
napFDAGHBC-ccmABCDEFGH
napFDAGHBC
ccmABCDEFGH


Transcriptional Regulation      
Display Regulation             
Activated by: FNR, FlhDC, NarP, ModE
Repressed by: NarL, NarP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Richard-Fogal C., Kranz RG., 2010, The CcmC:heme:CcmE complex in heme trafficking and cytochrome c biosynthesis., J Mol Biol 401(3):350-62

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