RegulonDB RegulonDB 11.1: Gene Form
   

hisQ gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

hisJ hisP hisM hisQ anti-anti-terminator anti-terminator

Gene      
Name: hisQ    Texpresso search in the literature
Synonym(s): ECK2302, EG12125, b2308
Genome position(nucleotides): 2425230 <-- 2425916
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.55
External database links:  
ASAP:
 ABE-0007615
CGSC:
 32721
ECHOBASE:
 EB2046
ECOLIHUB:
 hisQ
OU-MICROARRAY:
 b2308
STRING:
 511145.b2308
COLOMBOS: hisQ


Product      
Name: lysine/arginine/ornithine ABC transporter / histidine ABC transporter, membrane subunit HisQ
Synonym(s): HisQ
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 24.649
Isoelectric point: 9.268
Motif(s):
 
Type Positions Sequence Comment
13 -> 212 ALVTLELAISSVVLAVIIGLIGAGGKLSQNRLSGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNTVTEAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPSMMRYALPGIGNNWQVILKSTALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVL UniProt: ABC transmembrane type-1.
15 -> 15 V UniProt: In Ref. 1; AAA85770..
28 -> 219 VIIGLIGAGGKLSQNRLSGLIFEGYTTLIRGVPDLVLMLLIFYGLQIALNTVTEAMGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPSMMRYALPGIGNNWQVILKSTALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLFLERRY
59 -> 79 VPDLVLMLLIFYGLQIALNTV UniProt: Helical.
61 -> 61 D UniProt: In Ref. 1; AAA85770..

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.6 - other (mechanical, nutritional, oxidative stress)
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0097627 - high-affinity L-ornithine transmembrane transporter activity
GO:0005292 - high-affinity lysine transmembrane transporter activity
GO:0005289 - high-affinity L-arginine transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
GO:0005291 - high-affinity L-histidine transmembrane transporter activity
biological_process GO:0097639 - L-lysine import across plasma membrane
GO:0097638 - L-arginine import across plasma membrane
GO:0097640 - L-ornithine import across plasma membrane
GO:0006865 - amino acid transport
GO:0055085 - transmembrane transport
GO:0071705 - nitrogen compound transport
GO:0003333 - amino acid transmembrane transport
GO:0089718 - amino acid import across plasma membrane
GO:0089709 - L-histidine transmembrane transport
GO:1903810 - L-histidine import across plasma membrane
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P52094
DIP:
 DIP-9912N
ECOCYC:
 HISQ-MONOMER
ECOLIWIKI:
 b2308
INTERPRO:
 IPR010065
INTERPRO:
 IPR000515
INTERPRO:
 IPR035906
INTERPRO:
 IPR030199
PANTHER:
 PTHR30133:SF1
PFAM:
 PF00528
PRIDE:
 P52094
PRODB:
 PRO_000022902
PROSITE:
 PS50928
REFSEQ:
 NP_416811
SMR:
 P52094
UNIPROT:
 P52094


Operon      
Name: argT-hisJQMP         
Operon arrangement:
Transcription unit        Promoter
hisJQMP
argT-hisJQMP


Transcriptional Regulation      
Display Regulation             
Activated by: H-NS, NtrC
Repressed by: ArgR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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