RegulonDB RegulonDB 10.9: Gene Form
   

lgt gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ptsP lgt thyA anti-anti-terminator anti-terminator TSS_3131 TSS_3131 TSS_3130 TSS_3130 lgtp lgtp TSS_3129 TSS_3129 thyAp2 thyAp2 thyAp thyAp TSS_3128 (cluster) TSS_3128 (cluster)

Gene      
Name: lgt    Texpresso search in the literature
Synonym(s): ECK2824, EG12128, b2828, umpA
Genome position(nucleotides): 2965162 <-- 2966037 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.85
External database links:  
ASAP:
ABE-0009270
CGSC:
33350
ECHOBASE:
EB2049
ECOLIHUB:
lgt
OU-MICROARRAY:
b2828
STRING:
511145.b2828
COLOMBOS: lgt


Product      
Name: phosphatidylglycerol—prolipoprotein diacylglyceryl transferase
Synonym(s): Lgt, UmpA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 33.108
Isoelectric point: 9.721
Motif(s):
 
Type Positions Sequence
130 -> 150 FIAPLIPFGLGAGRLGNFING
139 -> 139 L
7 -> 7 H
26 -> 26 Y
196 -> 196 H

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.1 - phospholipid
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0009898 - cytoplasmic side of plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016740 - transferase activity
GO:0008961 - phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
biological_process GO:0042158 - lipoprotein biosynthetic process
Note(s): Note(s): ...[more].
Reference(s): [1] Chattopadhyay PK., et al., 1977
[2] Ovchinnikov S., et al., 2015
[3] Qi HY., et al., 1995
[4] Sankaran K., et al., 1994
[5] Tokunaga M., et al., 1982
External database links:  
ECOCYC:
EG12128-MONOMER
ECOLIWIKI:
b2828
INTERPRO:
IPR001640
PANTHER:
PTHR30589
PDB:
5AZB
PDB:
5AZC
PFAM:
PF01790
PRIDE:
P60955
PRODB:
PRO_000023088
PROSITE:
PS01311
REFSEQ:
NP_417305
SMR:
P60955
UNIPROT:
P60955


Operon      
Name: lgt-thyA         
Operon arrangement:
Transcription unit        Promoter
thyA
lgt
lgt-thyA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3128 (cluster) 2965245 reverse For this promoter, there
Read more >
[RS-EPT-CBR] [6]
  promoter thyAp2 2965348 reverse Similarity to the consensus
Read more >
[ICWHO] [7]
  promoter TSS_3129 2966117 reverse nd [RS-EPT-CBR] [6]
  promoter TSS_3130 2967019 reverse nd [RS-EPT-CBR] [6]
  promoter TSS_3131 2967163 reverse nd [RS-EPT-CBR] [6]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight



Reference(s)    

 [1] Chattopadhyay PK., Wu HC., 1977, Biosynthesis of the covalently linked diglyceride in murein lipoprotein of Escherichia coli., Proc Natl Acad Sci U S A 74(12):5318-22

 [2] Ovchinnikov S., Kinch L., Park H., Liao Y., Pei J., Kim DE., Kamisetty H., Grishin NV., Baker D., 2015, Large-scale determination of previously unsolved protein structures using evolutionary information., Elife 4:e09248

 [3] Qi HY., Sankaran K., Gan K., Wu HC., 1995, Structure-function relationship of bacterial prolipoprotein diacylglyceryl transferase: functionally significant conserved regions., J Bacteriol 177(23):6820-4

 [4] Sankaran K., Wu HC., 1994, Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol., J Biol Chem 269(31):19701-6

 [5] Tokunaga M., Tokunaga H., Wu HC., 1982, Post-translational modification and processing of Escherichia coli prolipoprotein in vitro., Proc Natl Acad Sci U S A 79(7):2255-9

 [6] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [7] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78


RegulonDB