RegulonDB RegulonDB 11.1: Gene Form
   

uspB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pitA uspA uspB FadR FadR IHF ppGpp ppGpp TSS_4101 (cluster) TSS_4101 (cluster) TSS_4100 (cluster) TSS_4100 (cluster) TSS_4099 TSS_4099 TSS_4098 TSS_4098 TSS_4097 (cluster) TSS_4097 (cluster) TSS_4096 (cluster) TSS_4096 (cluster) TSS_4095 (cluster) TSS_4095 (cluster) uspAp3 uspAp3 uspAp2 uspAp2 TSS_4093 (cluster) TSS_4093 (cluster) uspAp1 uspAp1 TSS_4092 (cluster) TSS_4092 (cluster) uspBp uspBp TSS_4091 TSS_4091

Gene      
Name: uspB    Texpresso search in the literature
Synonym(s): ECK3479, EG12231, b3494, yhiO
Genome position(nucleotides): 3639385 <-- 3639720
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 47.02
External database links:  
ASAP:
 ABE-0011410
ECHOBASE:
 EB2143
ECOLIHUB:
 uspB
OU-MICROARRAY:
 b3494
STRING:
 511145.b3494
COLOMBOS: uspB


Product      
Name: universal stress protein B
Synonym(s): UspB, YhiO, putative universal stress (ethanol tolerance) protein B
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 13.027
Isoelectric point: 9.004
Motif(s):
 
Type Positions Sequence Comment
1 -> 21 MISTVALFWALCVVCIVNMAR UniProt: Helical.
90 -> 110 FILTSALCGLVVVSLIALMIW UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations
  5 - cell processes --> 5.6 - protection --> 5.6.2 - detoxification
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0000725 - recombinational repair
GO:0045471 - response to ethanol
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Diez AA., et al., 2002
[2] Farewell A., et al., 1998
[3] Farewell A., et al., 1998
[4] Persson O., et al., 2010
External database links:  
ALPHAFOLD:
 P0A8S5
ECOCYC:
 EG12231-MONOMER
ECOLIWIKI:
 b3494
INTERPRO:
 IPR019598
PFAM:
 PF10625
PRIDE:
 P0A8S5
PRODB:
 PRO_000024191
REFSEQ:
 NP_417951
SMR:
 P0A8S5
UNIPROT:
 P0A8S5


Operon      
Name: uspB         
Operon arrangement:
Transcription unit        Promoter
uspB


Transcriptional Regulation      
Display Regulation             
Repressed by: IHF


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_4091 3639846 reverse nd [RS-EPT-CBR] [5]
  promoter TSS_4092 (cluster) 3639937 forward nd [RS-EPT-CBR] [5]
  promoter TSS_4093 (cluster) 3639984 forward nd [RS-EPT-CBR] [5]
  promoter TSS_4095 (cluster) 3640090 forward nd [RS-EPT-CBR] [5]
  promoter TSS_4096 (cluster) 3640126 forward nd [RS-EPT-CBR] [5]
  promoter TSS_4097 (cluster) 3640211 forward nd [RS-EPT-CBR] [5]
  promoter TSS_4098 3640229 forward nd [RS-EPT-CBR] [5]
  promoter TSS_4099 3640413 forward nd [RS-EPT-CBR] [5]
  promoter TSS_4100 (cluster) 3640418 forward nd [RS-EPT-CBR] [5]
  promoter TSS_4101 (cluster) 3640424 forward nd [RS-EPT-CBR] [5]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Diez AA., Tunlid A., Nystrom T., 2002, The Escherichia coli ftsK1 mutation attenuates the induction of sigma(S)-dependent genes upon transition to stationary phase., FEMS Microbiol Lett 206(1):19-23

 [2] Farewell A., Kvint K., Nystrom T., 1998, Negative regulation by RpoS: a case of sigma factor competition., Mol Microbiol 29(4):1039-51

 [3] Farewell A., Kvint K., Nystrom T., 1998, uspB, a new sigmaS-regulated gene in Escherichia coli which is required for stationary-phase resistance to ethanol., J Bacteriol 180(23):6140-7

 [4] Persson O., Nystrom T., Farewell A., 2010, UspB, a member of the sigma-S regulon, facilitates RuvC resolvase function., DNA Repair (Amst) 9(11):1162-9

 [5] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB