RegulonDB

Gene
Name:	yfeH
Synonym(s):	ECK2404, EG12376, b2410
Genome position(nucleotides):	2526946 --> 2527944 Genome Browser
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	51.75
External database links:

ASAP:	ABE-0007936
ECHOBASE:	EB2279
OU-MICROARRAY:	b2410
PortEco:	yfeH
STRING:	511145.b2410
COLOMBOS:	yfeH

Product

Name:

putative solute:Na⁺ symporter

Synonym(s):

YfeH

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

36.406

Isoelectric point:

9.94

Motif(s):

Type	Positions	Sequence
	8 -> 316	DPFTLTLITVVLLASFFPARGDFVPFFENLTTAAIALLFFMHGAKLSREAIIAGGGHWRLHLWVMCSTFVLFPILGVLFAWWKPVNVDPMLYSGFLYLCILPATVQSAIAFTSMAGGNVAAAVCSASASSLLGIFLSPLLVGLVMNVHGAGGSLEQVGKIMLQLLLPFVLGHLSRPWIGDWVSRNKKWIAKTDQTSILLVVYTAFSEAVVNGIWHKVGWGSLLFIVVVSCVLLAIVIVVNVFMARRLSFNKADEITIVFCGSKKSLANGIPMANILFPTSVIGMMVLPLMIFHQIQLMVCAVLARRYKR
	325 -> 332	QESSADKA

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		4 - transport --> 4.9.B - Putative uncharacterized transport protein
Gene Ontology Terms (GO)
	cellular_component	GO:0005886 - plasma membrane
	molecular_function	GO:0015293 - symporter activity
	biological_process	GO:0055085 - transmembrane transport

Note(s):

Note(s): ...[more].

Reference(s):

[1] Jindal S., et al., 2019

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

REFSEQ:

UNIPROT:

Operon

Name:

yfeH

Operon arrangement:

Transcription unit	Promoter
yfeH

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	yfeHp5	2526909	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.835. P-value: 6.252e-5 Read more >	[ICWHO]	[2]
promoter	TSS_2688	2526926	forward	nd	[RS-EPT-CBR]	[3]
promoter	yfeHp3	2526933	forward	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: 3.055. P-value: 9.421e-5 Read more >	[ICWHO]	[2]
promoter	yfeRp1	2527039	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: poor homology. Score: -2.4. P-value: 3.466e-5 Read more >	[ICWHO]	[2]

Evidence
[ICWHO] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.