RegulonDB RegulonDB 11.1: Gene Form
   

lhgD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gabD lhgD glaH Nac gabDp1 gabDp1 gabDp gabDp gabDp2 gabDp2

Gene      
Name: lhgD    Texpresso search in the literature
Synonym(s): ECK2654, EG12387, b2660, lhgO, ygaF
Genome position(nucleotides): 2789982 --> 2791250
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 57.68
External database links:  
ASAP:
 ABE-0008756
ECHOBASE:
 EB2288
ECOLIHUB:
 lhgO
MIM:
 236792
OU-MICROARRAY:
 b2660
STRING:
 511145.b2660
COLOMBOS: lhgD


Product      
Name: L-2-hydroxyglutarate dehydrogenase
Synonym(s): LhgD, LhgO, YgaF
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,inner membrane
Molecular weight: 46.082
Isoelectric point: 8.463
Motif(s):
 
Type Positions Sequence Comment
3 -> 390 DFVIIGGGIIGMSTAMQLIDVYPDARIALLEKESAPACHQTGHNSGVIHAGVYYTPGSLKAQFCLAGNRATKAFCDQNGIRYDNCGKMLVATSDLEMERMRALWERTAANGIEREWLNADELREREPNITGLGGIFVPSSGIVSYRDVTAAMAKIFQSRGGEIIYNAEVSGLNEHKNGVVIRTRQGGEYEASTLISCSGLMADRLVKMLGLEPGFIICPFRGEYFRLAPEHNQIVNHLIYPIPDPAMPFLGVHLTRMIDGSVTVGPNAVLAFKREGYRKRDFSFSDTLEILGSSGIRRVLQNHLRSGLGEMKNSLCKSGYLRLVQKYCPRLSLSDLQPWPAGVRAQAVSPDGKLIDDFLFVTTPRTIHTCNAPSPAATSAIPIGAHIV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0140696 - (S)-2-hydroxyglutarate dehydrogenase activity
GO:0005515 - protein binding
GO:0016491 - oxidoreductase activity
GO:0016901 - oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0047545 - 2-hydroxyglutarate dehydrogenase activity
GO:0050660 - flavin adenine dinucleotide binding
GO:0003973 - (S)-2-hydroxy-acid oxidase activity
biological_process GO:0006554 - lysine catabolic process
GO:0019477 - L-lysine catabolic process
Note(s): Note(s): ...[more].
External database links:  
ALPHAFOLD:
 P37339
DIP:
 DIP-12096N
ECOCYC:
 EG12387-MONOMER
ECOLIWIKI:
 b2660
INTERPRO:
 IPR030862
INTERPRO:
 IPR036188
INTERPRO:
 IPR006076
MODBASE:
 P37339
PFAM:
 PF01266
PRIDE:
 P37339
REFSEQ:
 NP_417146
UNIPROT:
 P37339


Operon      
Name: glaH-lhgD-gabDTP         
Operon arrangement:
Transcription unit        Promoter
csiD-ygaF-gabDTP
gabDTP
gabDTP
gabDTP


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, H-NS, Lrp
Repressed by: GlaR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



RegulonDB