RegulonDB RegulonDB 11.1: Gene Form
   

iaaA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

gsiA gsiB moeA iaaA NarL ArcA NarL FNR anti-anti-terminator anti-terminator terminator iaaAp iaaAp moeAp moeAp

Gene      
Name: iaaA    Texpresso search in the literature
Synonym(s): ECK0818, EG12407, b0828, spt, ybiK
Genome position(nucleotides): 866568 --> 867533
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.52
External database links:  
ASAP:
 ABE-0002828
ECHOBASE:
 EB2307
ECOLIHUB:
 iaaA
OU-MICROARRAY:
 b0828
STRING:
 511145.b0828
COLOMBOS: iaaA


Product      
Name: isoaspartyl dipeptidase proenzyme
Synonym(s): IaaA, Spt, YbiK
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol,periplasmic space
Molecular weight: 33.394
Isoelectric point: 4.558
Motif(s):
 
Type Positions Sequence Comment
2 -> 178 GKAVIAIHGGAGAISRAQMSLQQELRYIEALSAIVETGQKMLEAGESALDVVTEAVRLLEECPLFNAGIGAVFTRDETHELDACVMDGNTLKAGAVAGVSHLRNPVLAARLVMEQSPHVMMIGEGAENFAFARGMERVSPEIFSTSLRYEQLLAARKEGATVLDHSGAPLDEKQKMG UniProt: Isoaspartyl peptidase subunit alpha.
5 -> 310 VIAIHGGAGAISRAQMSLQQELRYIEALSAIVETGQKMLEAGESALDVVTEAVRLLEECPLFNAGIGAVFTRDETHELDACVMDGNTLKAGAVAGVSHLRNPVLAARLVMEQSPHVMMIGEGAENFAFARGMERVSPEIFSTSLRYEQLLAARKEGATVLDHSGAPLDEKQKMGTVGAVALDLDGNLAAATSTGGMTNKLPGRVGDSPLVGAGCYANNASVAVSCTGTGEVFIRALAAYDIAALMDYGGLSLAEACERVVMEKLPALGGSGGLIAIDHEGNVALPFNTEGMYRAWGYAGDTPTTGI
179 -> 179 T UniProt: Catalytically inactive..
207 -> 210 RVGD UniProt: Substrate binding; Sequence Annotation Type: region of interest.
230 -> 233 TGTG UniProt: Substrate binding; Sequence Annotation Type: region of interest.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.3 - amino acids
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0030288 - outer membrane-bounded periplasmic space
molecular_function GO:0008233 - peptidase activity
GO:0016787 - hydrolase activity
GO:0004067 - asparaginase activity
GO:0008798 - beta-aspartyl-peptidase activity
biological_process GO:0006508 - proteolysis
GO:0016540 - protein autoprocessing
External database links:  
ALPHAFOLD:
 P37595
ECOCYC:
 EG12407-MONOMER
ECOLIWIKI:
 b0828
INTERPRO:
 IPR029055
INTERPRO:
 IPR000246
MODBASE:
 P37595
PANTHER:
 PTHR10188
PDB:
 3C17
PDB:
 2ZAL
PDB:
 2ZAK
PDB:
 1T3M
PDB:
 1JN9
PDB:
 1K2X
PFAM:
 PF01112
PRIDE:
 P37595
PRODB:
 PRO_000022979
REFSEQ:
 NP_415349
SMR:
 P37595
SWISSMODEL:
 P37595
UNIPROT:
 P37595


Operon      
Name: iaaA-gsiABCD         
Operon arrangement:
Transcription unit        Promoter
iaaA-gsiABCD


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References



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