RegulonDB RegulonDB 11.1: Gene Form
   

lplT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aas lplT tas omrA omrAp omrAp TSS_3137 TSS_3137 TSS_3136 TSS_3136 lplTp3 lplTp3 TSS_3135 TSS_3135

Gene      
Name: lplT    Texpresso search in the literature
Synonym(s): ECK2831, EG12455, b2835, ygeD
Genome position(nucleotides): 2972669 <-- 2973862
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.53
External database links:  
ASAP:
 ABE-0009300
ECHOBASE:
 EB2349
ECOLIHUB:
 lplT
OU-MICROARRAY:
 b2835
STRING:
 511145.b2835
COLOMBOS: lplT


Product      
Name: lysophospholipid transporter
Synonym(s): LplT, YgeD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 41.656
Isoelectric point: 9.78
Motif(s):
 
Type Positions Sequence Comment
18 -> 38 AVIVAQFLSAFGDNALLFATL UniProt: Helical.
20 -> 354 IVAQFLSAFGDNALLFATLALLKAQFYPEWSQPILQMVFVGAYILFAPFVGQVADSFAKGRVMMFANGLKLLGAASICFGINPFLGYTLVGVGAAAYSPAKYGILGELTTGSKLVKANGLMEASTIAAILLGSVAGGVLADWHVLVALAACALAYGGAVVANIYIPKLAAARPGQSWNLINMTRSFLNACTSLWRNGETRFSLVGTSLFWGAGVTLRFLLVLWVPVALGITDNATPTYLNAMVAIGIVVGAGAAAKLVTLETVSRCMPAGILIGVVVLIFSLQHELLPAYALLMLIGVMGGFFVVPLNALLQERGKKSVGAGNAIAVQNLGENSA
53 -> 73 ILQMVFVGAYILFAPFVGQVA UniProt: Helical.
91 -> 111 LGAASICFGINPFLGYTLVGV UniProt: Helical.
145 -> 165 IAAILLGSVAGGVLADWHVLV UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport
  5 - cell processes --> 5.6 - protection
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005319 - lipid transporter activity
GO:0022857 - transmembrane transporter activity
GO:0051978 - lysophospholipid:sodium symporter activity
biological_process GO:0045332 - phospholipid translocation
GO:0006650 - glycerophospholipid metabolic process
GO:0006869 - lipid transport
GO:0055085 - transmembrane transport
GO:0051977 - lysophospholipid transport
Note(s): Note(s): ...[more].
Reference(s): [1] Lin Y., et al., 2019
External database links:  
ALPHAFOLD:
 P39196
ECOCYC:
 EG12455-MONOMER
ECOLIWIKI:
 b2835
INTERPRO:
 IPR023727
INTERPRO:
 IPR036259
INTERPRO:
 IPR011701
MODBASE:
 P39196
PFAM:
 PF07690
PRIDE:
 P39196
PRODB:
 PRO_000023111
REFSEQ:
 NP_417312
UNIPROT:
 P39196


Operon      
Name: aas-lplT         
Operon arrangement:
Transcription unit        Promoter
aas-lplT


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3135 2971604 forward nd [RS-EPT-CBR] [2]
  promoter lplTp3 2973939 reverse nd [COMP-AINF] [3]
  promoter TSS_3136 2975992 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_3137 2976050 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Lin Y., Zheng L., Bogdanov M., 2019, Measurement of Lysophospholipid Transport Across the Membrane Using Escherichia coli Spheroplasts., Methods Mol Biol 165-180

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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