RegulonDB RegulonDB 10.8: Gene Form
   

lplT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

aas lplT tas omrA omrAp omrAp TSS_3137 TSS_3137 TSS_3136 TSS_3136 lplTp3 lplTp3 TSS_3135 TSS_3135

Gene      
Name: lplT    Texpresso search in the literature
Synonym(s): ECK2831, EG12455, b2835, ygeD
Genome position(nucleotides): 2972669 <-- 2973862 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.53
External database links:  
ASAP:
 ABE-0009300
ECHOBASE:
 EB2349
OU-MICROARRAY:
 b2835
PortEco:
 lplT
STRING:
 511145.b2835
COLOMBOS: lplT


Product      
Name: lysophospholipid transporter
Synonym(s): LplT, YgeD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 41.656
Isoelectric point: 9.78
Motif(s):
 
Type Positions Sequence
305 -> 325 LLPAYALLMLIGVMGGFFVVP
367 -> 387 MIGIPVVPIGIGFGALFALAI
53 -> 73 ILQMVFVGAYILFAPFVGQVA
145 -> 165 IAAILLGSVAGGVLADWHVLV
167 -> 187 LAACALAYGGAVVANIYIPKL

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport
  5 - cell processes --> 5.6 - protection
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005319 - lipid transporter activity
GO:0022857 - transmembrane transporter activity
GO:0051978 - lysophospholipid:sodium symporter activity
biological_process GO:0045332 - phospholipid translocation
GO:0006650 - glycerophospholipid metabolic process
GO:0006869 - lipid transport
GO:0055085 - transmembrane transport
GO:0051977 - lysophospholipid transport
Note(s): Note(s): ...[more].
Reference(s): [1] Lin Y., et al., 2019
External database links:  
ECOCYC:
 EG12455-MONOMER
ECOLIWIKI:
 b2835
INTERPRO:
 IPR011701
INTERPRO:
 IPR036259
INTERPRO:
 IPR023727
MODBASE:
 P39196
PFAM:
 PF07690
PRIDE:
 P39196
PRODB:
 PRO_000023111
PROSITE:
 PS50850
REFSEQ:
 NP_417312
UNIPROT:
 P39196


Operon      
Name: aas-lplT         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_3135 2971604 forward nd [RS-EPT-CBR] [2]
  promoter lplTp3 2973939 reverse Similarity to the consensus
Read more > 		[ICWHO] [3]
  promoter TSS_3136 2975992 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_3137 2976050 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Lin Y., Zheng L., Bogdanov M., 2019, Measurement of Lysophospholipid Transport Across the Membrane Using Escherichia coli Spheroplasts., Methods Mol Biol 165-180

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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