RegulonDB RegulonDB 11.1: Gene Form
   

qseC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

qseC qseB ygiW ygiZ QseB BasR QseB ygiWp5 ygiWp5 qseBp1 qseBp1 qseBp2 qseBp2 ygiWp7 ygiWp7 TSS_3326 (cluster) TSS_3326 (cluster) ygiVp3 ygiVp3 ygiVp2 ygiVp2

Gene      
Name: qseC    Texpresso search in the literature
Synonym(s): ECK3017, EG12658, b3026, ygiY
Genome position(nucleotides): 3170484 --> 3171833
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.04
External database links:  
ASAP:
 ABE-0009938
ECHOBASE:
 EB2845
ECOLIHUB:
 qseC
OU-MICROARRAY:
 b3026
STRING:
 511145.b3026
COLOMBOS: qseC


Product      
Name: sensor histidine kinase QseC
Synonym(s): QseC, YgiY
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 50.282
Isoelectric point: 5.486
Motif(s):
 
Type Positions Sequence Comment
13 -> 33 LTLIFLILASVTWLLSSFVAW UniProt: Helical.
23 -> 158 VTWLLSSFVAWKQTTDNVDELFDTQLMLFAKRLSTLDLNEINAADRMAQTPNRLKHGHVDDDALTFAIFTHDGRMVLNDGDNGEDIPYSYQREGFADGQLVGEDDPWRFVWMTSPDGKYRIVVGQEWEYREDMALA
157 -> 177 LAIVAGQLIPWLVALPIMLII UniProt: Helical.
238 -> 301 RRFTSDAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDS
243 -> 449 DAAHELRSPLTALKVQTEVAQLSDDDPQARKKALLQLHSGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSSVMDIYHTAQQAKIDVRLTLNAHSIKRTGQPLLLSLLVRNLLDNAVRYSPQGSVVDVTLNADNFIVRDNGPGVTPEALARIGERFYRPPGQTATGSGLGLSIVQRIAKLHGMNVEFGNAEQGGFEAKVSW UniProt: Histidine kinase.

 
Classification:
Multifun Terms (GenProtEC)  
  2 - information transfer --> 2.3 - protein related --> 2.3.3 - posttranslational modification
  3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.4 - complex regulation --> 3.1.2.4.3 - two component regulatory systems (external signal)
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.2 - covalent modification, demodification, maturation
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016740 - transferase activity
GO:0016772 - transferase activity, transferring phosphorus-containing groups
GO:0016301 - kinase activity
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0000155 - phosphorelay sensor kinase activity
GO:0004673 - protein histidine kinase activity
biological_process GO:0090593 - peptidyl-histidine autophosphorylation
GO:0016310 - phosphorylation
GO:0000160 - phosphorelay signal transduction system
GO:0007165 - signal transduction
GO:0018106 - peptidyl-histidine phosphorylation
GO:0044010 - single-species biofilm formation
GO:2000145 - regulation of cell motility
Note(s): Note(s): ...[more].
Evidence: [COMP-HINF-FN-FROM-SEQ] Human inference of function from sequence
Reference(s): [1] Oshima T., et al., 2002
[2] Schaller A., et al., 2002
[3] Shimada T., et al., 2013
[4] Sperandio V., et al., 2002
[5] Yamamoto K., et al., 2005
External database links:  
ALPHAFOLD:
 P40719
DISPROT:
 DP00774
ECOCYC:
 EG12658-MONOMER
ECOLIWIKI:
 b3026
INTERPRO:
 IPR036097
INTERPRO:
 IPR036890
INTERPRO:
 IPR013727
INTERPRO:
 IPR005467
INTERPRO:
 IPR004358
INTERPRO:
 IPR003661
INTERPRO:
 IPR003594
MODBASE:
 P40719
PDB:
 3JZ3
PDB:
 2KSE
PFAM:
 PF02518
PFAM:
 PF08521
PFAM:
 PF00512
PRIDE:
 P40719
PRINTS:
 PR00344
PRODB:
 PRO_000023667
PROSITE:
 PS50109
REFSEQ:
 NP_417498
SMART:
 SM00387
SMART:
 SM00388
SMR:
 P40719
UNIPROT:
 P40719


Operon      
Name: qseBC         
Operon arrangement:
Transcription unit        Promoter
qseBC
qseBC


Transcriptional Regulation      
Display Regulation             
Activated by: BasR, QseB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ygiVp2 3169287 reverse nd [COMP-AINF] [6]
  promoter ygiVp3 3169291 reverse nd [COMP-AINF] [6]
  promoter TSS_3326 (cluster) 3169416 reverse nd [RS-EPT-CBR] [7]
  promoter ygiWp7 3169688 reverse nd [COMP-AINF] [6]
  promoter ygiWp5 3169887 reverse nd [COMP-AINF] [6]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Oshima T., Aiba H., Masuda Y., Kanaya S., Sugiura M., Wanner BL., Mori H., Mizuno T., 2002, Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12., Mol Microbiol 46(1):281-91

 [2] Schaller A., Guo M., Gisanrin O., Zhang Y., 2002, Escherichia coli genes involved in resistance to pyrazinoic acid, the active component of the tuberculosis drug pyrazinamide., FEMS Microbiol Lett 211(2):265-70

 [3] Shimada T., Kori A., Ishihama A., 2013, Involvement of the ribose operon repressor RbsR in regulation of purine nucleotide synthesis in Escherichia coli., FEMS Microbiol Lett 344(2):159-65

 [4] Sperandio V., Torres AG., Kaper JB., 2002, Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli., Mol Microbiol 43(3):809-21

 [5] Yamamoto K., Hirao K., Oshima T., Aiba H., Utsumi R., Ishihama A., 2005, Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli., J Biol Chem 280(2):1448-56

 [6] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [7] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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