RegulonDB

RegulonDB RegulonDB 10.9: Gene Form

gltK gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	gltK
Synonym(s):	ECK0646, EG12662, b0653
Genome position(nucleotides):	685255 <-- 685929 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	50.22
External database links:

ASAP:	ABE-0002234
ECHOBASE:	EB2528
ECOLIHUB:	gltK
OU-MICROARRAY:	b0653
STRING:	511145.b0653
COLOMBOS:	gltK

Product

Name:

glutamate/aspartate ABC transporter membrane subunit GltK

Synonym(s):

GltK

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

24.915

Isoelectric point:

9.721

Motif(s):

Type	Positions	Sequence
	68 -> 88	LVMVLLWFYLIVPGFLQNVLG
	95 -> 112	IRLISAMVAFSMFEAAYY
	155 -> 175	VPLLLTQGIVLFQDTSLVYVL
	34 -> 223	GILWGTMLAVMRLSSFAPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRT
	197 -> 217	MILFAGFVYFVISLSASLLVS

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.1 - glutamate
		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.5 - aspartate
		6 - cell structure --> 6.1 - membrane
		4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane GO:0043190 - ATP-binding cassette (ABC) transporter complex
	molecular_function	GO:0022857 - transmembrane transporter activity
	biological_process	GO:0006865 - amino acid transport GO:0055085 - transmembrane transport GO:0071705 - nitrogen compound transport GO:1901998 - toxin transport

Note(s):

Note(s): ...[more].

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

PANTHER:

PANTHER:

PFAM:

PRIDE:

PRODB:

PROSITE:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

gltI-sroC-gltJKL

Operon arrangement:

Transcription unit	Promoter
gltIJKL-sroC	gltIp1
gltI-sroC-gltJKL	gltIp

Transcriptional Regulation
	Display Regulation
Activated by:	FlhDC

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	hscCp5	683482	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.513. P-value: 7.192e-5 Read more >	[ICWHO]	[1]
promoter	hscCp7	683594	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 6.613. P-value: 2.123e-5 Read more >	[ICWHO]	[1]
promoter	TSS_777 (cluster)	684440	reverse	For this promoter, there is a cluster of 3 transcription start sites,in the interval 684438 to 684440, where the highest frequency is at position 683662. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]
promoter	rihAp3	684602	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.236. P-value: 2.394e-5 Read more >	[ICWHO]	[1]

Evidence
[ICWHO] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)
[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78
[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

Reference(s)

[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

RegulonDB