RegulonDB

RegulonDB RegulonDB 10.8: Gene Form

gltL gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	gltL
Synonym(s):	ECK0645, EG12663, b0652
Genome position(nucleotides):	684530 <-- 685255 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	52.34
External database links:

ASAP:	ABE-0002232
ECHOBASE:	EB2529
OU-MICROARRAY:	b0652
PortEco:	gltL
STRING:	511145.b0652
COLOMBOS:	gltL

Product

Name:

glutamate/aspartate ABC transporter ATP binding subunit

Synonym(s):

GltL

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

26.661

Isoelectric point:

7.132

Motif(s):

Type	Positions	Sequence
	2 -> 236	ITLKNVSKWYGHFQVLTDCSTEVKKGEVVVVCGPSGSGKSTLIKTVNGLEPVQQGEITVDGIVVNDKKTDLAKLRSRVGMVFQHFELFPHLSIIENLTLAQVKVLKRDKAPAREKALKLLERVGLSAHANKFPAQLSGGQQQRVAIARALCMDPIAMLFDEPTSALDPEMINEVLDVMVELANEGMTMMVVTHEMGFARKVANRVIFMDEGKIVEDSPKDAFFDDPKSDRAKDFL
	137 -> 140	LSGG
	17 -> 165	LTDCSTEVKKGEVVVVCGPSGSGKSTLIKTVNGLEPVQQGEITVDGIVVNDKKTDLAKLRSRVGMVFQHFELFPHLSIIENLTLAQVKVLKRDKAPAREKALKLLERVGLSAHANKFPAQLSGGQQQRVAIARALCMDPIAMLFDEPTS
	34 -> 41	GPSGSGKS
	157 -> 164	AMLFDEPT

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.1 - glutamate
		1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.5 - aspartate
		4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.a - ABC superfamily ATP binding cytoplasmic component
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0043190 - ATP-binding cassette (ABC) transporter complex
	molecular_function	GO:0015599 - ATPase-coupled L-glutamine transmembrane transporter activity GO:0016887 - ATPase activity GO:0000166 - nucleotide binding GO:0005524 - ATP binding GO:0015424 - ATPase-coupled amino acid transmembrane transporter activity GO:0015426 - ATPase-coupled polar amino acid-transporter activity
	biological_process	GO:0006865 - amino acid transport GO:0003333 - amino acid transmembrane transport GO:0006868 - glutamine transport

Note(s):

Note(s): ...[more].

External database links:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MINT:

MODBASE:

PANTHER:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

SWISSMODEL:

UNIPROT:

Operon

Name:

gltI-sroC-gltJKL

Operon arrangement:

Transcription unit	Promoter
gltIJKL-sroC	gltIp1
gltI-sroC-gltJKL	gltIp

Transcriptional Regulation
	Display Regulation
Activated by:	FlhDC

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	hscCp5	683482		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.513. P-value: 7.192e-5 Read more >	[ICWHO]	[1]
	promoter	hscCp7	683594		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 6.613. P-value: 2.123e-5 Read more >	[ICWHO]	[1]
	promoter	TSS_777 (cluster)	684440		reverse	For this promoter, there is a cluster of 3 transcription start sites,in the interval 684438 to 684440, where the highest frequency is at position 683662. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[2]
	promoter	rihAp3	684602		reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: good homology. Score: 3.236. P-value: 2.394e-5 Read more >	[ICWHO]	[1]

Evidence
[ICWHO] Inferred computationally without human oversight
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

Reference(s)

[1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

[2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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