RegulonDB RegulonDB 10.8: Gene Form
   

lpxH gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

lpxH purE ppiB purK PurR TSS_675 TSS_675 TSS_674 (cluster) TSS_674 (cluster) purEp purEp

Gene      
Name: lpxH    Texpresso search in the literature
Synonym(s): ECK0517, EG12666, b0524, ybbF
Genome position(nucleotides): 553218 <-- 553940 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 54.5
External database links:  
ASAP:
 ABE-0001804
ECHOBASE:
 EB2532
OU-MICROARRAY:
 b0524
PortEco:
 lpxH
STRING:
 511145.b0524
COLOMBOS: lpxH


Product      
Name: UDP-2,3-diacylglucosamine diphosphatase
Synonym(s): LpxH, YbbF
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,cytosol
Molecular weight: 26.894
Isoelectric point: 7.761
Motif(s):
 
Type Positions Sequence
79 -> 80 NR
1 -> 203 MATLFIADLHLCVEEPAITAGFLRFLAGEARKADALYILGDLFEAWIGDDDPNPLHRKMAAAIKAVSDSGVPCYFIHGNRDFLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDTLCTDDAGYQAFRAKVHKPWLQTLFLALPLFVRKRIAARMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQVQWLIHGHTHRPAVHE

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.3 - lipopolysaccharide --> 1.6.3.3 - lipid A
  6 - cell structure --> 6.3 - surface antigens (ECA, O antigen of LPS)
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0019897 - extrinsic component of plasma membrane
GO:0005886 - plasma membrane
GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane
molecular_function GO:0016787 - hydrolase activity
GO:0016462 - pyrophosphatase activity
GO:0046872 - metal ion binding
GO:0008758 - UDP-2,3-diacylglucosamine hydrolase activity
GO:0030145 - manganese ion binding
biological_process GO:0006629 - lipid metabolic process
GO:0009245 - lipid A biosynthetic process
Note(s): Note(s): ...[more].
Reference(s): [1] Takayama K., et al., 1983
External database links:  
DIP:
 DIP-10125N
ECOCYC:
 EG12666-MONOMER
ECOLIWIKI:
 b0524
INTERPRO:
 IPR024654
INTERPRO:
 IPR010138
MODBASE:
 P43341
PANTHER:
 PTHR34990:SF1
PDB:
 5WLY
PFAM:
 PF12850
PRIDE:
 P43341
PRODB:
 PRO_000023124
REFSEQ:
 NP_415057
SMR:
 P43341
UNIPROT:
 P43341


Operon      
Name: ppiB-lpxH         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_674 (cluster) 554360 reverse For this promoter, there
Read more > 		[RS-EPT-CBR] [2]
  promoter TSS_675 554367 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Takayama K., Qureshi N., Mascagni P., Nashed MA., Anderson L., Raetz CR., 1983, Fatty acyl derivatives of glucosamine 1-phosphate in Escherichia coli and their relation to lipid A. Complete structure of A diacyl GlcN-1-P found in a phosphatidylglycerol-deficient mutant., J Biol Chem 258(12):7379-85

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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