RegulonDB RegulonDB 10.9: Gene Form
   

dctA gene in Escherichia coli K-12 genome

Gene      
Name: dctA    Texpresso search in the literature
Synonym(s): ECK3513, EG20044, b3528
Genome position(nucleotides): 3682161 <-- 3683447 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
51.67
External database links:  
ASAP:
ABE-0011527
CGSC:
872
ECHOBASE:
EB4140
ECOLIHUB:
dctA
OU-MICROARRAY:
b3528
STRING:
511145.b3528
COLOMBOS: dctA


Product      
Name: C4 dicarboxylate/orotate:H+ symporter
Synonym(s): DctA, DctA DAACS transporter, SBP2
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 45.436
Isoelectric point: 9.063
Motif(s):
 
Type Positions Sequence
219 -> 241 LGQLIICFYITCILFVVLVLGSI
352 -> 374 IVLAATLSAVGHLPVAGLALILG
184 -> 206 VIFGIINMIMRLAPIGAFGAMAF
47 -> 64 MIIAPVIFCTVVTGIAGM
9 -> 401 LYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIAGMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVYADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIESFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLGSIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLSAVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKW

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  3 - regulation --> 3.1 - type of regulation --> 3.1.4 - unknown
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
GO:0015293 - symporter activity
GO:0015183 - L-aspartate transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
GO:0015138 - fumarate transmembrane transporter activity
GO:0015141 - succinate transmembrane transporter activity
GO:0015366 - malate:proton symporter activity
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0006835 - dicarboxylic acid transport
GO:0015741 - fumarate transport
GO:0070778 - L-aspartate transmembrane transport
GO:0071422 - succinate transmembrane transport
GO:0071423 - malate transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
[2] Rayman MK., et al., 1972
External database links:  
DIP:
DIP-47958N
ECOCYC:
DCTA-MONOMER
ECOLIWIKI:
b3528
INTERPRO:
IPR001991
INTERPRO:
IPR036458
INTERPRO:
IPR023954
INTERPRO:
IPR018107
PFAM:
PF00375
PRIDE:
P0A830
PRODB:
PRO_000022410
PROSITE:
PS00713
PROSITE:
PS00714
REFSEQ:
NP_417985
UNIPROT:
P0A830


Operon      
Name: dctA         
Operon arrangement:
Transcription unit        Promoter
dctA


Transcriptional Regulation      
Display Regulation             
Activated by: CRP, DcuR
Repressed by: ArcA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Rayman MK., Lo TC., Sanwal BD., 1972, Transport of succinate in Escherichia coli. II. Characteristics of uptake and energy coupling with transport in membrane preparations., J Biol Chem 247(19):6332-9


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