RegulonDB RegulonDB 10.9: Gene Form
   

mgtS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ydeE mgtT mgrR mgtS PhoP mgrRp mgrRp mgtSp mgtSp TSS_1843 TSS_1843

Gene      
Name: mgtS    Texpresso search in the literature
Synonym(s): ECK4409, G0-8892, b4599, yneM
Genome position(nucleotides): 1622646 --> 1622741 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
38.54
External database links:  
ECOLIHUB:
yneM
STRING:
511145.b4599
COLOMBOS: mgtS


Product      
Name: small protein MgtS
Synonym(s): MgtS, YneM
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 3.509
Isoelectric point: 5.41
Motif(s):
 
Type Positions Sequence
31 -> 31 D
4 -> 26 NMNVFMAVLGIILFSGFLAAYFS
30 -> 30 D

 

Classification:
Multifun Terms (GenProtEC)  
  5 - cell processes --> 5.5 - adaptations --> 5.5.3 - starvation
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0005515 - protein binding
biological_process GO:0010960 - magnesium ion homeostasis
GO:0010350 - cellular response to magnesium starvation
Note(s): Note(s): ...[more].
Evidence: [IGI] Inferred from genetic interaction
[IMP] Inferred from mutant phenotype
[IPI] Inferred from physical interaction
Reference(s): [1] Duval M., et al., 2017
[2] Wang H., et al., 2017
External database links:  
ECOCYC:
MONOMER0-766
ECOLIWIKI:
b4599
PDB:
5OQT
PDB:
6F34
PRIDE:
A5A616
REFSEQ:
YP_001165319
SMR:
A5A616
UNIPROT:
A5A616


Operon      
Name: mgtS         
Operon arrangement:
Transcription unit        Promoter
mgtS


Transcriptional Regulation      
Display Regulation             
Activated by: PhoP


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1843 1622587 forward nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Duval M., Cossart P., 2017, Small bacterial and phagic proteins: an updated view on a rapidly moving field., Curr Opin Microbiol 39:81-88

 [2] Wang H., Yin X., Wu Orr M., Dambach M., Curtis R., Storz G., 2017, Increasing intracellular magnesium levels with the 31-amino acid MgtS protein., Proc Natl Acad Sci U S A 114(22):5689-5694

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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