RegulonDB

Gene
Name:	hokE
Synonym(s):	ECK0574, G0-9582, b4415, ybdY
Genome position(nucleotides):	607836 --> 607988
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	47.71
External database links:

ASAP:	ABE-0047279
ECHOBASE:	EB4049
ECOLIHUB:	hokE
STRING:	511145.b4415
COLOMBOS:	hokE

Product

Name:

protein HokE

Synonym(s):

HokE, YbdY

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

periplasmic space,inner membrane

Molecular weight:

5.564

Isoelectric point:

8.2

Motif(s):

Type	Positions	Sequence	Comment
	5 -> 25	YALAAVIVLCLTVLGFTLLVG	UniProt: Helical.

Classification:

Multifun Terms (GenProtEC)
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0030288 - outer membrane-bounded periplasmic space GO:0005886 - plasma membrane GO:0005887 - integral component of plasma membrane GO:0016021 - integral component of membrane
	biological_process	GO:0006974 - cellular response to DNA damage stimulus

Note(s):

Note(s): ...[more].

Evidence:

[HIFS] Human inference of function from sequence

Reference(s):

[1] Faridani OR., et al., 2006
[2] Pedersen K., et al., 1999

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

PFAM:

PRIDE:

PRINTS:

PROSITE:

REFSEQ:

UNIPROT:

Operon

Name:

hokE

Operon arrangement:

Transcription unit	Promoter
hokE	hokEp

Transcriptional Regulation
	Display Regulation
Repressed by:	LexA

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
	promoter	insLp5	608056		forward	nd	[ICWHO]	[3]

Evidence
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Faridani OR., Nikravesh A., Pandey DP., Gerdes K., Good L., 2006, Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated cell killing in Escherichia coli., Nucleic Acids Res 34(20):5915-22
[2] Pedersen K., Gerdes K., 1999, Multiple hok genes on the chromosome of Escherichia coli., Mol Microbiol 32(5):1090-102
[3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78