RegulonDB RegulonDB 11.1: Gene Form
   

hokE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

insL2 hokE sokE b4700 insLp5 insLp5

Gene      
Name: hokE    Texpresso search in the literature
Synonym(s): ECK0574, G0-9582, b4415, ybdY
Genome position(nucleotides): 607836 --> 607988
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 47.71
External database links:  
ASAP:
 ABE-0047279
ECHOBASE:
 EB4049
ECOLIHUB:
 hokE
STRING:
 511145.b4415
COLOMBOS: hokE


Product      
Name: protein HokE
Synonym(s): HokE, YbdY
Sequence: Get amino acid sequence Fasta Format
Cellular location: periplasmic space,inner membrane
Molecular weight: 5.564
Isoelectric point: 8.2
Motif(s):
 
Type Positions Sequence Comment
5 -> 25 YALAAVIVLCLTVLGFTLLVG UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
biological_process GO:0006974 - cellular response to DNA damage stimulus
Note(s): Note(s): ...[more].
Evidence: [COMP-HINF-FN-FROM-SEQ] Human inference of function from sequence
Reference(s): [1] Faridani OR., et al., 2006
[2] Pedersen K., et al., 1999
External database links:  
ALPHAFOLD:
 P77091
ECOCYC:
 MONOMER0-1581
ECOLIWIKI:
 b4415
INTERPRO:
 IPR000021
INTERPRO:
 IPR018084
PFAM:
 PF01848
PRIDE:
 P77091
PRINTS:
 PR00281
PROSITE:
 PS00556
REFSEQ:
 YP_025295
UNIPROT:
 P77091


Operon      
Name: hokE         
Operon arrangement:
Transcription unit        Promoter
hokE


Transcriptional Regulation      
Display Regulation             
Repressed by: LexA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter insLp5 608056 forward nd [COMP-AINF] [3]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Faridani OR., Nikravesh A., Pandey DP., Gerdes K., Good L., 2006, Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated cell killing in Escherichia coli., Nucleic Acids Res 34(20):5915-22

 [2] Pedersen K., Gerdes K., 1999, Multiple hok genes on the chromosome of Escherichia coli., Mol Microbiol 32(5):1090-102

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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