RegulonDB RegulonDB 10.8: Gene Form
   

nanT gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

nanT nanA nanE nanK terminator

Gene      
Name: nanT    Texpresso search in the literature
Synonym(s): ECK3213, G436, b3224
Genome position(nucleotides): 3371084 <-- 3372574 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
55.06
External database links:  
ASAP:
ABE-0010577
CGSC:
18121
ECHOBASE:
EB4145
OU-MICROARRAY:
b3224
PortEco:
nanT
STRING:
511145.b3224
COLOMBOS: nanT


Product      
Name: N-acetylneuraminate:H+ symporter
Synonym(s): NanT
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 53.551
Isoelectric point: 9.838
Motif(s):
 
Type Positions Sequence
278 -> 298 VMLMVVVLFAFLYSWPIQALL
406 -> 426 FTYNVGALGGALAPIIGALIA
431 -> 451 LGTALASLSFSLTFVVILLIG
22 -> 42 FSAAWLGYLLDGFDFVLIALV
355 -> 375 IIPVFAIGGANVWVLGLLLFF

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.12 - amino sugar conversions
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0046943 - carboxylic acid transmembrane transporter activity
GO:0015144 - carbohydrate transmembrane transporter activity
GO:0005351 - carbohydrate:proton symporter activity
GO:0022857 - transmembrane transporter activity
GO:0015136 - sialic acid transmembrane transporter activity
GO:0015538 - sialic acid:proton symporter activity
biological_process GO:0008643 - carbohydrate transport
GO:0046942 - carboxylic acid transport
GO:0015739 - sialic acid transport
GO:0055085 - transmembrane transport
GO:0034219 - carbohydrate transmembrane transport
GO:1902600 - proton transmembrane transport
GO:1905039 - carboxylic acid transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
[2] Martinez J., et al., 1995
External database links:  
ECOCYC:
NANT-MONOMER
ECOLIWIKI:
b3224
INTERPRO:
IPR011701
INTERPRO:
IPR036259
INTERPRO:
IPR020846
INTERPRO:
IPR004742
MODBASE:
P41036
PFAM:
PF07690
PRIDE:
P41036
PROSITE:
PS50850
REFSEQ:
NP_417691
SMR:
P41036
UNIPROT:
P41036


Operon      
Name: nanATEK-yhcH         
Operon arrangement:
Transcription unit        Promoter
nanA
nanATEK-yhcH


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: NanR, Fis


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Martinez J., Steenbergen S., Vimr E., 1995, Derived structure of the putative sialic acid transporter from Escherichia coli predicts a novel sugar permease domain., J Bacteriol 177(20):6005-10


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