RegulonDB

Gene
Name:	yafN
Synonym(s):	ECK0233, G6116, b0232
Genome position(nucleotides):	252005 --> 252298
Strand:	forward
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	42.18
External database links:

ASAP:	ABE-0000793
ECHOBASE:	EB2945
ECOLIHUB:	yafN
OU-MICROARRAY:	b0232
STRING:	511145.b0232
COLOMBOS:	yafN

Product

Name:

antitoxin YafN

Synonym(s):

YafN, antitoxin of the YafO-YafN toxin-antitoxin system

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

11.234

Isoelectric point:

5.219

Classification:

Multifun Terms (GenProtEC)
Multifun Terms (GenProtEC)		3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.3 - inhibition / activation of enzymes
Gene Ontology Terms (GO)
	cellular_component	GO:0110001 - toxin-antitoxin complex GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0005515 - protein binding
	biological_process	GO:0006281 - DNA repair GO:0006355 - regulation of transcription, DNA-templated GO:0006974 - cellular response to DNA damage stimulus GO:0009432 - SOS response GO:0040008 - regulation of growth GO:0044092 - negative regulation of molecular function

Note(s):

Note(s): ...[more].

Evidence:

[IDA] Inferred from direct assay

Reference(s):

External database links:

ALPHAFOLD:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PRIDE:

REFSEQ:

UNIPROT:

Operon

Name:

dinB-yafNOP

Operon arrangement:

Transcriptional Regulation
	Display Regulation
Repressed by:	LexA

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Lee MC., Franco M., Vargas DM., Hudman DA., White SJ., Fowler RG., Sargentini NJ., 2014, A ΔdinB mutation that sensitizes Escherichia coli to the lethal effects of UV- and X-radiation., Mutat Res 763-764:19-27
[2] Zhang F., Xing L., Teng M., Li X., 2012, Crystallization and preliminary crystallographic studies of the YafN-YafO complex from Escherichia coli., Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 8):894-7
[3] Zhang Y., Yamaguchi Y., Inouye M., 2009, Characterization of YafO, an Escherichia coli Toxin., J Biol Chem 284(38):25522-31