RegulonDB RegulonDB 11.0: Gene Form
   

yafN gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dinB yafO yafN LexA yafNp yafNp

Gene      
Name: yafN    Texpresso search in the literature
Synonym(s): ECK0233, G6116, b0232
Genome position(nucleotides): 252005 --> 252298
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
42.18
External database links:  
ASAP:
ABE-0000793
ECHOBASE:
EB2945
ECOLIHUB:
yafN
OU-MICROARRAY:
b0232
STRING:
511145.b0232
COLOMBOS: yafN


Product      
Name: antitoxin YafN
Synonym(s): YafN, antitoxin of the YafO-YafN toxin-antitoxin system
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 11.234
Isoelectric point: 5.219
Classification:
Multifun Terms (GenProtEC)  
  3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional --> 3.1.3.3 - inhibition / activation of enzymes
Gene Ontology Terms (GO)  
cellular_component GO:0110001 - toxin-antitoxin complex
GO:0005829 - cytosol
molecular_function GO:0003677 - DNA binding
GO:0005515 - protein binding
biological_process GO:0006281 - DNA repair
GO:0006355 - regulation of transcription, DNA-templated
GO:0006974 - cellular response to DNA damage stimulus
GO:0009432 - SOS response
GO:0040008 - regulation of growth
GO:0044092 - negative regulation of molecular function
Note(s): Note(s): ...[more].
Evidence: [IDA] Inferred from direct assay
Reference(s): [1] Lee MC., et al., 2014
[2] Zhang F., et al., 2012
[3] Zhang Y., et al., 2009
External database links:  
ALPHAFOLD:
Q47156
ECOCYC:
G6116-MONOMER
ECOLIWIKI:
b0232
INTERPRO:
IPR036165
PRIDE:
Q47156
REFSEQ:
NP_414767
UNIPROT:
Q47156


Operon      
Name: dinB-yafNOP         
Operon arrangement:
Transcription unit        Promoter
dinB-yafNOP
dinB-yafNOP
yafNOP


Transcriptional Regulation      
Display Regulation             
Repressed by: LexA


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Lee MC., Franco M., Vargas DM., Hudman DA., White SJ., Fowler RG., Sargentini NJ., 2014, A ΔdinB mutation that sensitizes Escherichia coli to the lethal effects of UV- and X-radiation., Mutat Res 763-764:19-27

 [2] Zhang F., Xing L., Teng M., Li X., 2012, Crystallization and preliminary crystallographic studies of the YafN-YafO complex from Escherichia coli., Acta Crystallogr Sect F Struct Biol Cryst Commun 68(Pt 8):894-7

 [3] Zhang Y., Yamaguchi Y., Inouye M., 2009, Characterization of YafO, an Escherichia coli Toxin., J Biol Chem 284(38):25522-31


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