RegulonDB

RegulonDB RegulonDB 11.2: Gene Form

prpR gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	prpR
Synonym(s):	ECK0328, G6195, b0330, yahP
Genome position(nucleotides):	346857 <-- 348443
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	55.2
External database links:

ASAP:	ABE-0001133
ECHOBASE:	EB3369
ECOLIHUB:	prpR
OU-MICROARRAY:	b0330
STRING:	511145.b0330
COLOMBOS:	prpR

Product

Name:

DNA-binding transcriptional dual regulator PrpR

Synonym(s):

PrpR, YahP

Sequence:

Get amino acid sequence Fasta Format

Regulator Family:

EBP

Cellular location:

cytosol

Molecular weight:

58.649

Isoelectric point:

8.434

Motif(s):

Type	Positions	Sequence	Comment
	36 -> 196	LANITPIQLGFEKAVTYIRKKLANERCDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIPALVAFQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIYSAATVRQAFSDALDMTRMS
	218 -> 461	MLGQSPQMEQVRQTILLYARSSAAVLIEGETGTGKELAAQAIHREYFARHDARQGKKSHPFVAVNCGAIAESLLEAELFGYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQPVPVDVRVISATHCNLEEDMQQGRFRRDLFYRLSILRLQLPPLRERVADILPLAESFLKVSLAALSAPFSAALRQGLQASETVLLHYDWPGNIRELRNMMERLALF	UniProt: Sigma-54 factor interaction.
	219 -> 393	LGQSPQMEQVRQTILLYARSSAAVLIEGETGTGKELAAQAIHREYFARHDARQGKKSHPFVAVNCGAIAESLLEAELFGYEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKEVTRVGGHQPVPVDVRVISATHCNLEEDMQQGRFRRDLFYRLSILRL
	318 -> 327	AHGGTLFLDE	UniProt: ATP.
	498 -> 527	QQALEKFNGDKTAAANYLGISRTTFWRRLK

Classification:

Multifun Terms (GenProtEC)
		1 - metabolism --> 1.1 - carbon utilization --> 1.1.2 - fatty acids
		2 - information transfer --> 2.2 - RNA related --> 2.2.2 - Transcription related
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.2 - activator
		3 - regulation --> 3.1 - type of regulation --> 3.1.2 - transcriptional level --> 3.1.2.3 - repressor
		3 - regulation --> 3.3 - genetic unit regulated --> 3.3.1 - operon
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm GO:0005829 - cytosol
	molecular_function	GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0000166 - nucleotide binding GO:0005524 - ATP binding GO:0000156 - phosphorelay response regulator activity GO:0043565 - sequence-specific DNA binding
	biological_process	GO:0006355 - regulation of transcription, DNA-templated GO:0045892 - negative regulation of transcription, DNA-templated GO:0045893 - positive regulation of transcription, DNA-templated GO:0000160 - phosphorelay signal transduction system GO:0009314 - response to radiation GO:0019629 - propionate catabolic process, 2-methylcitrate cycle

Evidence:

[EXP-IDA] Inferred from direct assay

Reference(s):

[1] Lee SK., et al., 2005
[2] Sargentini NJ., et al., 2016

External database links:

ALPHAFOLD:

DIP:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

MODBASE:

PDB:

PFAM:

PFAM:

PFAM:

PRIDE:

PRODB:

PROSITE:

PROSITE:

PROSITE:

REFSEQ:

SMART:

SMR:

SWISSMODEL:

UNIPROT:

Operon

Name:

prpR

Operon arrangement:

Transcription unit	Promoter
prpR	prpRp

Transcriptional Regulation
	Display Regulation
Activated by:	CRP
Repressed by:	PrpR, PhoB, AscG

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Lee SK., Newman JD., Keasling JD., 2005, Catabolite repression of the propionate catabolic genes in Escherichia coli and Salmonella enterica: evidence for involvement of the cyclic AMP receptor protein., J Bacteriol 187(8):2793-800
[2] Sargentini NJ., Gularte NP., Hudman DA., 2016, Screen for genes involved in radiation survival of Escherichia coli and construction of a reference database., Mutat Res 793-794:1-14

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