RegulonDB RegulonDB 10.8: Gene Form
   

fsr gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ybaL ushA fsr TSS_645 TSS_645 ushAp6 ushAp6 TSS_644 TSS_644 fsrp9 fsrp9 fsrp5 fsrp5 fsrp6 fsrp6 fsrp8 fsrp8 ybaLp ybaLp

Gene      
Name: fsr    Texpresso search in the literature
Synonym(s): ECK0473, G6256, b0479
Genome position(nucleotides): 503476 <-- 504696 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.42
External database links:  
ASAP:
ABE-0001661
ECHOBASE:
EB3054
OU-MICROARRAY:
b0479
PortEco:
fsr
STRING:
511145.b0479
COLOMBOS: fsr


Product      
Name: fosmidomycin efflux pump
Synonym(s): Fsr
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 43.306
Isoelectric point: 10.087
Motif(s):
 
Type Positions Sequence
103 -> 123 GLVLLALAGSFGAVLLAAALV
267 -> 287 LHLFAFLFAVAAGTVIGGPVG
152 -> 172 IFQVGGNFGSSLGPLLAAVII
295 -> 315 VIWGSILGVAPFTLILPYASL
379 -> 399 IELVYKICAFLPLLGMLTIFL

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  5 - cell processes --> 5.6 - protection --> 5.6.4 - drug resistance/sensitivity
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0022857 - transmembrane transporter activity
biological_process GO:0006974 - cellular response to DNA damage stimulus
GO:0046677 - response to antibiotic
GO:0055085 - transmembrane transport
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
FSR-MONOMER
ECOLIWIKI:
b0479
INTERPRO:
IPR011701
INTERPRO:
IPR036259
INTERPRO:
IPR020846
MODBASE:
P52067
PFAM:
PF07690
PRIDE:
P52067
PRODB:
PRO_000022711
PROSITE:
PS50850
REFSEQ:
NP_415012
UNIPROT:
P52067


Operon      
Name: fsr         
Operon arrangement:
Transcription unit        Promoter
 


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter fsrp8 504767 reverse Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter fsrp6 504847 reverse Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter fsrp5 504852 reverse Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter fsrp9 504855 reverse Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_644 504883 forward nd [RS-EPT-CBR] [2]
  promoter ushAp6 504886 forward Similarity to the consensus
Read more >
[ICWHO] [1]
  promoter TSS_645 504888 forward nd [RS-EPT-CBR] [2]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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