RegulonDB RegulonDB 11.0: Gene Form
   

fetB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

qmcA cnoX fetB fetA ybbJ TSS_661 TSS_661 fetAp fetAp ybbLp6 ybbLp6 TSS_659 (cluster) TSS_659 (cluster) qmcAp qmcAp ybbJp1 ybbJp1

Gene      
Name: fetB    Texpresso search in the literature
Synonym(s): ECK0485, G6267, b0491, ybbM
Genome position(nucleotides): 516583 --> 517362
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 46.15
External database links:  
ASAP:
 ABE-0001705
ECHOBASE:
 EB3048
ECOLIHUB:
 ybbM
OU-MICROARRAY:
 b0491
STRING:
 511145.b0491
COLOMBOS: fetB


Product      
Name: putative iron ABC exporter membrane subunit FetB
Synonym(s): FetB, YbbM
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 28.165
Isoelectric point: 10.145
Motif(s):
 
Type Positions Sequence Comment
6 -> 26 ITNESLALALMLVVVAILISH UniProt: Helical.
10 -> 245 SLALALMLVVVAILISHKEKLALEKDILWSVGRAIIQLIIVGYVLKYIFSVDDASLTLLMVLFICFNAAWNAQKRSKYIAKAFISSFIAITVGAGITLAVLILSGSIEFIPMQVIPIAGMIAGNAMVAVGLCYNNLGQRVISEQQQIQEKLSLGATPKQASAILIRDSIRAALIPTVDSAKTVGLVSLPGMMSGLIFAGIDPVKAIKYQIMVTFMLLSTASLSTIIACYLTYRKFY
36 -> 56 ILWSVGRAIIQLIIVGYVLKY UniProt: Helical.
57 -> 77 IFSVDDASLTLLMVLFICFNA UniProt: Helical.
92 -> 112 FISSFIAITVGAGITLAVLIL UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.9.B - Putative uncharacterized transport protein
  5 - cell processes --> 5.5 - adaptations --> 5.5.7 - Fe aquisition
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
biological_process GO:0006811 - ion transport
GO:0006879 - cellular iron ion homeostasis
GO:0055072 - iron ion homeostasis
Note(s): Note(s): ...[more].
Evidence: [IGI] Inferred from genetic interaction
[IMP] Inferred from mutant phenotype
Reference(s): [1] Kumar A., et al., 2016
[2] Nicolaou SA., et al., 2013
External database links:  
ALPHAFOLD:
 P77307
ECOCYC:
 G6267-MONOMER
ECOLIWIKI:
 b0491
INTERPRO:
 IPR005226
PANTHER:
 PTHR30028
PFAM:
 PF03649
PRIDE:
 P77307
REFSEQ:
 NP_415024
UNIPROT:
 P77307


Operon      
Name: fetAB         
Operon arrangement:
Transcription unit        Promoter
fetAB


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ybbJp1 515077 reverse nd [ICWHO] [3]
  promoter TSS_659 (cluster) 515825 reverse nd [RS-EPT-CBR] [4]
  promoter ybbLp6 515892 forward nd [ICWHO], [RS-EPT-CBR] [3], [4]
  promoter TSS_661 518264 reverse nd [RS-EPT-CBR] [4]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Kumar A., Beloglazova N., Bundalovic-Torma C., Phanse S., Deineko V., Gagarinova A., Musso G., Vlasblom J., Lemak S., Hooshyar M., Minic Z., Wagih O., Mosca R., Aloy P., Golshani A., Parkinson J., Emili A., Yakunin AF., Babu M., 2016, Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli., Cell Rep 14(3):648-61

 [2] Nicolaou SA., Fast AG., Nakamaru-Ogiso E., Papoutsakis ET., 2013, Overexpression of fetA (ybbL) and fetB (ybbM), Encoding an Iron Exporter, Enhances Resistance to Oxidative Stress in Escherichia coli., Appl Environ Microbiol 79(23):7210-9

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [4] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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