RegulonDB RegulonDB 11.0: Gene Form
   

allC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

allC allD allE ylbAp2 ylbAp2

Gene      
Name: allC    Texpresso search in the literature
Synonym(s): ECK0509, G6285, b0516, glxB7, ylbB
Genome position(nucleotides): 544057 <-- 545292
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 51.38
External database links:  
ASAP:
 ABE-0001777
ECHOBASE:
 EB3388
ECOLIHUB:
 allC
OU-MICROARRAY:
 b0516
STRING:
 511145.b0516
COLOMBOS: allC


Product      
Name: allantoate amidohydrolase
Synonym(s): AllC, YlbB
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 45.694
Isoelectric point: 5.054
Motif(s):
 
Type Positions Sequence Comment
79 -> 405 GSHIDTVVNGGNLDGQFGALAAWLAIDWLKTQYGAPLRTVEVVAMAEEEGSRFPYVFWGSKNIFGLANPDDVRNICDAKGNSFVDAMKACGFTLPNAPLTPRQDIKAFVELHIEQGCVLESNGQSIGVVNAIVGQRRYTVTLNGESNHAGTTPMGYRRDTVYAFSRICHQSVEKAKRMGDPLVLTFGKVEPRPNTVNVVPGKTTFTIDCRHTDAAVLRDFTQQLENDMRAICDEMDIGIDIDLWMDEEPVPMNKELVATLTELCEREKLNYRVMHSGAGHDAQIFAPRVPTCMIFIPSINGISHNPAERTNITDLAEGVKTLALMLY
126 -> 126 E UniProt: Loss of amidohydrolase activity. Large movement of the catalytic domain into a closed conformation..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.26 - allantoin assimilation
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.3 - nitrogen metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016787 - hydrolase activity
GO:0046872 - metal ion binding
GO:0008270 - zinc ion binding
GO:0016813 - hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 - manganese ion binding
GO:0042803 - protein homodimerization activity
GO:0047652 - allantoate deiminase activity
biological_process GO:0000256 - allantoin catabolic process
GO:0009442 - allantoin assimilation pathway
GO:0006144 - purine nucleobase metabolic process
External database links:  
ALPHAFOLD:
 P77425
DIP:
 DIP-9088N
ECOCYC:
 G6285-MONOMER
ECOLIWIKI:
 b0516
INTERPRO:
 IPR036264
INTERPRO:
 IPR017591
INTERPRO:
 IPR010158
INTERPRO:
 IPR002933
MODBASE:
 P77425
PANTHER:
 PTHR32494
PDB:
 4PXD
PDB:
 2IMO
PDB:
 1Z2L
PFAM:
 PF01546
PRIDE:
 P77425
PRODB:
 PRO_000022081
REFSEQ:
 NP_415049
SMR:
 P77425
SWISSMODEL:
 P77425
UNIPROT:
 P77425


Operon      
Name: allDCE         
Operon arrangement:
Transcription unit        Promoter
allDC-ylbA


Transcriptional Regulation      
Display Regulation             
Activated by: AllS


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ylbAp2 544056 reverse nd [ICWHO] [1]


Evidence    

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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