RegulonDB RegulonDB 11.1: Gene Form
   

allD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

fdrA allC allD AllS anti-anti-terminator anti-terminator terminator fdrAp4 fdrAp4 allDp allDp

Gene      
Name: allD    Texpresso search in the literature
Synonym(s): ECK0510, G6286, b0517, glxB8, ylbC
Genome position(nucleotides): 545314 <-- 546363
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.38
External database links:  
ASAP:
 ABE-0001780
ECHOBASE:
 EB3389
ECOLIHUB:
 allD
OU-MICROARRAY:
 b0517
STRING:
 511145.b0517
COLOMBOS: allD


Product      
Name: ureidoglycolate dehydrogenase
Synonym(s): AllD, YlbC
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 37.967
Isoelectric point: 6.122
Motif(s):
 
Type Positions Sequence Comment
3 -> 331 ISRETLHQLIENKLCQAGLKREHAATVAEVLVYADARGIHSHGAVRVEYYAERISKGGTNREPEFRLEETGPCSAILHADNAAGQVAAKMGMEHAIKTAQQNGVAVVGISRMGHSGAISYFVQQAARAGFIGISMCQSDPMVVPFGGAEIYYGTNPLAFAAPGEGDEILTFDMATTVQAWGKVLDARSRNMSIPDTWAVDKNGVPTTDPFAVHALLPAAGPKGYGLMMMIDVLSGVLLGLPFGRQVSSMYDDLHAGRNLGQLHIVINPNFFSSSELFRQHLSQTMRELNAITPAPGFNQVYYPGQDQDIKQRKAAVEGIEIVDDIYQYL
43 -> 43 S UniProt: 4- and 10-fold decrease of the affinity for NAD and (S)-ureidoglycolate, respectively. Strong decrease of the catalytic efficiency..
44 -> 44 H UniProt: 16-fold decrease of the affinity for (S)-ureidoglycolate, but same affinity for NAD compared to the wild-type. Strong decrease of the catalytic efficiency..
48 -> 48 R UniProt: Loss of dehydrogenase activity..
52 -> 52 Y UniProt: 2- and 16-fold decrease of the affinity for NAD and (S)-ureidoglycolate, respectively. Strong decrease of the catalytic efficiency..

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.26 - allantoin assimilation
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.3 - nitrogen metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016491 - oxidoreductase activity
GO:0009040 - ureidoglycolate dehydrogenase activity
biological_process GO:0000256 - allantoin catabolic process
GO:0009442 - allantoin assimilation pathway
GO:0006144 - purine nucleobase metabolic process
External database links:  
ALPHAFOLD:
 P77555
ECOCYC:
 G6286-MONOMER
ECOLIWIKI:
 b0517
INTERPRO:
 IPR036111
INTERPRO:
 IPR017590
INTERPRO:
 IPR043144
INTERPRO:
 IPR003767
INTERPRO:
 IPR043143
MODBASE:
 P77555
PANTHER:
 PTHR11091
PDB:
 1XRH
PDB:
 4H8A
PFAM:
 PF02615
PRIDE:
 P77555
PRODB:
 PRO_000022082
REFSEQ:
 NP_415050
SMR:
 P77555
UNIPROT:
 P77555


Operon      
Name: allDCE         
Operon arrangement:
Transcription unit        Promoter
allDC-ylbA


Transcriptional Regulation      
Display Regulation             
Activated by: AllS


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter fdrAp4 546506 forward nd [COMP-AINF] [1]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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