RegulonDB RegulonDB 10.8: Gene Form
   

dcuC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

dcuC dpiA pagP dpiB DinJ-YafQ SlyA PhoP SlyA ArcA SlyA FNR FNR FNR Cis-reg; thermoregulator terminator pagPp pagPp dcuCp dcuCp TSS_749 TSS_749

Gene      
Name: dcuC    Texpresso search in the literature
Synonym(s): ECK0614, G6347, b0621
Genome position(nucleotides): 654583 <-- 655968 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
50.94
External database links:  
ASAP:
ABE-0002133
ECHOBASE:
EB3315
OU-MICROARRAY:
b0621
PortEco:
dcuC
STRING:
511145.b0621
COLOMBOS: dcuC


Product      
Name: anaerobic C4-dicarboxylate transporter DcuC
Synonym(s): DcuC
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 48.412
Isoelectric point: 8.287
Motif(s):
 
Type Positions Sequence
2 -> 22 LTFIELLIGVVVIVGVARYII
164 -> 184 AICASPAAIILAPTSGDVVLA
436 -> 456 VLVGLVIVIVATELMVPGTAA
116 -> 136 PYLLMIAAYFVACLMSLAVSS
240 -> 260 TTAPAFYAILPFTPIIGVLIF

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.1 - carbon utilization --> 1.1.1 - carbon compounds
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0015556 - C4-dicarboxylate transmembrane transporter activity
GO:0005469 - succinate:fumarate antiporter activity
biological_process GO:0015740 - C4-dicarboxylate transport
GO:0015741 - fumarate transport
GO:0019664 - mixed acid fermentation
GO:0071422 - succinate transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Engel P., et al., 1992
External database links:  
ECOCYC:
DCUC-MONOMER
ECOLIWIKI:
b0621
INTERPRO:
IPR004669
INTERPRO:
IPR018385
PANTHER:
PTHR42002
PFAM:
PF03606
PRIDE:
P0ABP3
PRODB:
PRO_000022414
REFSEQ:
NP_415154
SMR:
P0ABP3
UNIPROT:
P0ABP3


Operon      
Name: dcuC         
Operon arrangement:
Transcription unit        Promoter
dcuC


Transcriptional Regulation      
Display Regulation             
Activated by: FNR, ArcA


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_749 656023 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Engel P., Kramer R., Unden G., 1992, Anaerobic fumarate transport in Escherichia coli by an fnr-dependent dicarboxylate uptake system which is different from the aerobic dicarboxylate uptake system., J Bacteriol 174(17):5533-9

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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