RegulonDB

RegulonDB RegulonDB 10.8: Gene Form

zitB gene in Escherichia coli K-12 genome

Gene local context to scale (view description)

Gene
Name:	zitB
Synonym(s):	ECK0741, G6393, b0752, ybgR
Genome position(nucleotides):	783882 <-- 784823 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	53.08
External database links:

ASAP:	ABE-0002549
ECHOBASE:	EB3426
MIM:	125853
OU-MICROARRAY:	b0752
PortEco:	zitB
STRING:	511145.b0752
COLOMBOS:	zitB

Product

Name:

Zn²⁺/Cd²⁺/Ni²⁺/Cu²⁺ exporter

Synonym(s):

YbgR, ZitB, ZitB zinc CDF transporter

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

inner membrane

Molecular weight:

34.678

Isoelectric point:

6.825

Motif(s):

Type	Positions	Sequence
	21 -> 41	LLYAFGVTAGFMLVEVVGGFL
	90 -> 110	AAFVNAIALVVITILIVWEAI
	22 -> 213	LYAFGVTAGFMLVEVVGGFLSGSLALLADAGHMLTDTAALLFALLAVQFSRRPPTIRHTFGWLRLTTLAAFVNAIALVVITILIVWEAIERFRTPRPVEGGMMMAIAVAGLLANILSFWLLHHGSEEKNLNVRAAALHVLGDLLGSVGAIIAALIIIWTGWTPADPILSILVSLLVLRSAWRLLKDSVNELL
	122 -> 142	GMMMAIAVAGLLANILSFWLL
	160 -> 180	VLGDLLGSVGAIIAALIIIWT

Classification:

Multifun Terms (GenProtEC)
		4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
		6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)
	cellular_component	GO:0016020 - membrane GO:0005886 - plasma membrane GO:0016021 - integral component of membrane
	molecular_function	GO:0008324 - cation transmembrane transporter activity GO:0005385 - zinc ion transmembrane transporter activity
	biological_process	GO:0006811 - ion transport GO:0006812 - cation transport GO:0006829 - zinc ion transport GO:0055085 - transmembrane transport GO:0071577 - zinc ion transmembrane transport GO:0098655 - cation transmembrane transport

Note(s):

Note(s): ...[more].

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

INTERPRO:

INTERPRO:

INTERPRO:

PANTHER:

PFAM:

PRIDE:

PRODB:

REFSEQ:

SMR:

UNIPROT:

Operon

Name:

zitB

Operon arrangement:

Transcription unit	Promoter

Elements in the selected gene context region unrelated to any object in RegulonDB

Type	Name	Post Left	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References
promoter	TSS_902	782098	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_903 (cluster)	782352	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 782352 to 782353, where the highest frequency is at position 781575. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
promoter	TSS_904 (cluster)	782372	forward	For this promoter, there is a cluster of 3 transcription start sites,in the interval 782372 to 782374, where the highest frequency is at position 781596. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
promoter	TSS_905	782376	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_906 (cluster)	782394	forward	For this promoter, there is a cluster of 2 transcription start sites,in the interval 782394 to 782395, where the highest frequency is at position 781617. The most upstream position of this cluster is assigned as TSS position in the promoter. Read more >	[RS-EPT-CBR]	[1]
promoter	TSS_907	782424	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_908	783540	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_909	783611	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_910	783630	forward	nd	[RS-EPT-CBR]	[1]
promoter	TSS_911	784191	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_912	784253	reverse	nd	[RS-EPT-CBR]	[1]
promoter	TSS_913	784403	reverse	nd	[RS-EPT-CBR]	[1]
promoter	zitBp1	784848	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.023. P-value: 6.773e-5 Read more >	[ICWHO]	[2]
promoter	zitBp2	784858	reverse	Similarity to the consensus sequence of the set of known functional promoters for this sigma factor with strong experimental evidence: high homology. Score: 4.23. P-value: 4.027e-5 Read more >	[ICWHO]	[2]

Evidence
[RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates
[ICWHO] Inferred computationally without human oversight

Reference(s)
[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.
[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

Reference(s)

[1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

[2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

RegulonDB