RegulonDB RegulonDB 10.10: Gene Form
   

pgl gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

pgl ybhD ybhA ybhHp8 ybhHp8 ybhAp6 ybhAp6 pglp2 pglp2 ybhAp10 ybhAp10 TSS_938 (cluster) TSS_938 (cluster)

Gene      
Name: pgl    Texpresso search in the literature
Synonym(s): ECK0756, G6397, b0767, ybhE
Genome position(nucleotides): 798586 --> 799581 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.12
External database links:  
ASAP:
 ABE-0002611
ECHOBASE:
 EB3020
ECOLIHUB:
 pgl
OU-MICROARRAY:
 b0767
STRING:
 511145.b0767
COLOMBOS: pgl


Product      
Name: 6-phosphogluconolactonase
Synonym(s): Pgl, YbhE
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 36.308
Isoelectric point: 4.927
Motif(s):
 
Type Positions Sequence
5 -> 327 VYIASPESQQIHVWNLNHEGALTLTQVVDVPGQVQPMVVSPDKRYLYVGVRPEFRVLAYRIAPDDGALTFAAESALPGSPTHISTDHQGQFVFVGSYNAGNVSVTRLEDGLPVGVVDVVEGLDGCHSANISPDNRTLWVPALKQDRICLFTVSDDGHLVAQDPAEVTTVEGAGPRHMVFHPNEQYAYCVNELNSSVDVWELKDPHGNIECVQTLDMMPENFSDTRWAADIHITPDGRHLYACDRTASLITVFSVSEDGSVLSKEGFQPTETQPRGFNVDHSGKYLIAAGQKSHHISVYEIVGEQGLLHEKGRYAVGQGPMWVV
37 -> 52 QVQPMVVSPDKRYLYV
319 -> 331 VGQGPMWVVVNAH

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.3 - energy metabolism, carbon --> 1.3.2 - pentose pwy, oxidative branch
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016787 - hydrolase activity
GO:0017057 - 6-phosphogluconolactonase activity
biological_process GO:0005975 - carbohydrate metabolic process
GO:0006006 - glucose metabolic process
GO:0006098 - pentose-phosphate shunt
Note(s): Note(s): ...[more].
External database links:  
ECOCYC:
 6PGLUCONOLACT-MONOMER
ECOLIWIKI:
 b0767
INTERPRO:
 IPR022528
INTERPRO:
 IPR019405
INTERPRO:
 IPR015943
INTERPRO:
 IPR011045
MODBASE:
 P52697
PDB:
 1RI6
PFAM:
 PF10282
PRIDE:
 P52697
PRODB:
 PRO_000024852
REFSEQ:
 NP_415288
SMR:
 P52697
SWISSMODEL:
 P52697
UNIPROT:
 P52697


Operon      
Name: pgl         
Operon arrangement:
Transcription unit        Promoter
pgl


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_938 (cluster) 798458 reverse nd [RS-EPT-CBR] [1]
  promoter ybhAp10 798537 reverse nd [ICWHO] [2]
  promoter pglp2 798539 forward nd [ICWHO] [2]
  promoter ybhAp6 798592 reverse nd [ICWHO] [2]
  promoter ybhHp8 800552 forward nd [ICWHO] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

RegulonDB