RegulonDB RegulonDB 11.1: Gene Form
   

ybhR gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ybhS ybhR ybhP ybhQ ybhF clsB ybhQp ybhQp

Gene      
Name: ybhR    Texpresso search in the literature
Synonym(s): ECK0781, G6409, b0792
Genome position(nucleotides): 825002 <-- 826108
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 52.3
External database links:  
ASAP:
 ABE-0002701
ECHOBASE:
 EB3438
ECOLIHUB:
 ybhR
OU-MICROARRAY:
 b0792
STRING:
 511145.b0792
COLOMBOS: ybhR


Product      
Name: ABC exporter membrane subunit YbhR
Synonym(s): YbhR
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 41.566
Isoelectric point: 9.385
Motif(s):
 
Type Positions Sequence Comment
25 -> 45 ILILPVLIQVILFPFAATLEV UniProt: Helical.
129 -> 366 AQIAANYLQQIVKNYQQELLEGKPKPNNSELVVRNWYNPNLDYKWFVVPSLIAMITTIGVMIVTSLSVAREREQGTLDQLLVSPLTTWQIFIGKAVPALIVATFQATIVLAIGIWAYQIPFAGSLALFYFTMVIYGLSLVGFGLLISSLCSTQQQAFIGVFVFMMPAILLSGYVSPVENMPVWLQNLTWINPIRHFTDITKQIYLKDASLDIVWNSLWPLLVITATTGSAAYAMFRRK UniProt: ABC transmembrane type-2.
174 -> 194 FVVPSLIAMITTIGVMIVTSL UniProt: Helical.
223 -> 243 AVPALIVATFQATIVLAIGIW UniProt: Helical.
254 -> 274 ALFYFTMVIYGLSLVGFGLLI UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0015562 - efflux transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:1990961 - xenobiotic detoxification by transmembrane export across the plasma membrane
GO:0015904 - tetracycline transmembrane transport
GO:0090452 - lithium ion transmembrane transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0006855 - xenobiotic transmembrane transport
GO:0055085 - transmembrane transport
GO:0035725 - sodium ion transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Griffith JM., et al., 2019
[2] Jindal S., et al., 2019
External database links:  
ALPHAFOLD:
 P0AFP9
DIP:
 DIP-48088N
ECOCYC:
 YBHR-MONOMER
ECOLIWIKI:
 b0792
INTERPRO:
 IPR000412
PFAM:
 PF12698
PRIDE:
 P0AFP9
PRINTS:
 PR00164
PROSITE:
 PS51012
REFSEQ:
 NP_415313
SMR:
 P0AFP9
UNIPROT:
 P0AFP9


Operon      
Name: cecR-ybhGFSR         
Operon arrangement:
Transcription unit        Promoter
cecR-ybhGFSR


Transcriptional Regulation      
Display Regulation             
Repressed by: CecR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Griffith JM., Basting PJ., Bischof KM., Wrona EP., Kunka KS., Tancredi AC., Moore JP., Hyman MRL., Slonczewski JL., 2019, Experimental Evolution of Escherichia coli K-12 in the Presence of Proton Motive Force (PMF) Uncoupler Carbonyl Cyanide m -Chlorophenylhydrazone Selects for Mutations Affecting PMF-Driven Drug Efflux Pumps., Appl Environ Microbiol 85(5)

 [2] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

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