RegulonDB RegulonDB 11.1: Gene Form
   

ybhS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ybhF ybhS ybhR ybhG ybhQ TSS_955 TSS_955 TSS_954 TSS_954 TSS_953 TSS_953

Gene      
Name: ybhS    Texpresso search in the literature
Synonym(s): ECK0782, G6410, b0793
Genome position(nucleotides): 826119 <-- 827252
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.11
External database links:  
ASAP:
 ABE-0002703
ECHOBASE:
 EB3439
ECOLIHUB:
 ybhS
OU-MICROARRAY:
 b0793
STRING:
 511145.b0793
COLOMBOS: ybhS


Product      
Name: ABC exporter membrane subunit YbhS
Synonym(s): YbhS
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 42.06
Isoelectric point: 8.434
Motif(s):
 
Type Positions Sequence Comment
29 -> 49 WLIAVVIPLLLLFIFGYGINL UniProt: Helical.
145 -> 375 IWQIWQMQRAEDNGQTFEPLIDVQTRYWFNPAAISQHFIIPGAVTIIMTVIGAILTSLVVAREWERGTMEALLSTEITRTELLLCKLIPYYFLGMLAMLLCMLVSVFILGVPYRGSLLILFFISSLFLLSTLGMGLLISTITRNQFNAAQVALNAAFLPSIMLSGFIFQIDSMPAVIRAVTYIIPARYFVSTLQSLFLAGNIPVVLVVNVLFLIASAVMFIGLTWLKTKRR UniProt: ABC transmembrane type-2.
182 -> 202 FIIPGAVTIIMTVIGAILTSL UniProt: Helical.
235 -> 255 YFLGMLAMLLCMLVSVFILGV UniProt: Helical.
262 -> 282 LILFFISSLFLLSTLGMGLLI UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  6 - cell structure --> 6.1 - membrane
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.m - ABC superfamily, membrane component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0015562 - efflux transmembrane transporter activity
GO:0022857 - transmembrane transporter activity
biological_process GO:1990961 - xenobiotic detoxification by transmembrane export across the plasma membrane
GO:0015904 - tetracycline transmembrane transport
GO:0090452 - lithium ion transmembrane transport
GO:0006855 - xenobiotic transmembrane transport
GO:0055085 - transmembrane transport
GO:0035725 - sodium ion transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
ALPHAFOLD:
 P0AFQ2
ECOCYC:
 YBHS-MONOMER
ECOLIWIKI:
 b0793
INTERPRO:
 IPR000412
PFAM:
 PF12698
PRIDE:
 P0AFQ2
PROSITE:
 PS51012
REFSEQ:
 NP_415314
SMR:
 P0AFQ2
UNIPROT:
 P0AFQ2


Operon      
Name: cecR-ybhGFSR         
Operon arrangement:
Transcription unit        Promoter
cecR-ybhGFSR


Transcriptional Regulation      
Display Regulation             
Repressed by: CecR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_953 829107 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_954 829469 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_955 829473 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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