RegulonDB RegulonDB 11.1: Gene Form
   

ybhF gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

ybhF ybhS ybhR ybhG cecR ybhQ TSS_957 TSS_957 TSS_956 TSS_956 TSS_955 TSS_955 TSS_954 TSS_954 TSS_953 TSS_953

Gene      
Name: ybhF    Texpresso search in the literature
Synonym(s): ECK0783, G6411, b0794
Genome position(nucleotides): 827245 <-- 828981
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.56
External database links:  
ASAP:
 ABE-0002707
ECHOBASE:
 EB3098
ECOLIHUB:
 ybhF
OU-MICROARRAY:
 b0794
STRING:
 511145.b0794
COLOMBOS: ybhF


Product      
Name: ABC exporter ATP binding subunit YbhF
Synonym(s): YbhF
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 63.132
Isoelectric point: 5.397
Motif(s):
 
Type Positions Sequence Comment
6 -> 237 ITLNGLEKRFPGMDKPAVAPLDCTIHAGYVTGLVGPDGAGKTTLMRMLAGLLKPDSGSATVIGFDPIKNDGALHAVLGYMPQKFGLYEDLTVMENLNLYADLRSVTGEARKQTFARLLEFTSLGPFTGRLAGKLSGGMKQKLGLACTLVGEPKVLLLDEPGVGVDPISRRELWQMVHELAGEGMLILWSTSYLDEAEQCRDVLLMNEGELLYQGEPKALTQTMAGRSFLMTS UniProt: ABC transporter 1.
26 -> 165 LDCTIHAGYVTGLVGPDGAGKTTLMRMLAGLLKPDSGSATVIGFDPIKNDGALHAVLGYMPQKFGLYEDLTVMENLNLYADLRSVTGEARKQTFARLLEFTSLGPFTGRLAGKLSGGMKQKLGLACTLVGEPKVLLLDEP
40 -> 47 GPDGAGKT UniProt: ATP 1.
330 -> 559 IEAKELTKKFGDFAATDHVNFAVKRGEIFGLLGPNGAGKSTTFKMMCGLLVPTSGQALVLGMDLKESSGKARQHLGYMAQKFSLYGNLTVEQNLRFFSGVYGLRGRAQNEKISRMSEAFGLKSIASHATDELPLGFKQRLALACSLMHEPDILFLDEPTSGVDPLTRREFWLHINSMVEKGVTVMVTTHFMDEAEYCDRIGLVYRGKLIASGTPDDLKAQSANDEQPDPT UniProt: ABC transporter 2.
346 -> 489 DHVNFAVKRGEIFGLLGPNGAGKSTTFKMMCGLLVPTSGQALVLGMDLKESSGKARQHLGYMAQKFSLYGNLTVEQNLRFFSGVYGLRGRAQNEKISRMSEAFGLKSIASHATDELPLGFKQRLALACSLMHEPDILFLDEPTS

 
Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.a - ABC superfamily ATP binding cytoplasmic component
Gene Ontology Terms (GO)  
cellular_component GO:0005886 - plasma membrane
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
molecular_function GO:0005515 - protein binding
GO:0000166 - nucleotide binding
GO:0005524 - ATP binding
GO:0015562 - efflux transmembrane transporter activity
biological_process GO:1990961 - xenobiotic detoxification by transmembrane export across the plasma membrane
GO:0015904 - tetracycline transmembrane transport
GO:0090452 - lithium ion transmembrane transport
GO:0006855 - xenobiotic transmembrane transport
GO:0035725 - sodium ion transmembrane transport
Note(s): Note(s): ...[more].
Reference(s): [1] Jindal S., et al., 2019
External database links:  
ALPHAFOLD:
 P0A9U1
DIP:
 DIP-48149N
ECOCYC:
 YBHF-MONOMER
ECOLIWIKI:
 b0794
INTERPRO:
 IPR017871
INTERPRO:
 IPR027417
INTERPRO:
 IPR003593
INTERPRO:
 IPR003439
MODBASE:
 P0A9U1
PFAM:
 PF00005
PRIDE:
 P0A9U1
PROSITE:
 PS00211
PROSITE:
 PS50893
REFSEQ:
 NP_415315
SMART:
 SM00382
SMR:
 P0A9U1
UNIPROT:
 P0A9U1


Operon      
Name: cecR-ybhGFSR         
Operon arrangement:
Transcription unit        Promoter
cecR-ybhGFSR


Transcriptional Regulation      
Display Regulation             
Repressed by: CecR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_953 829107 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_954 829469 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_955 829473 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_956 830082 reverse nd [RS-EPT-CBR] [2]
  promoter TSS_957 830088 reverse nd [RS-EPT-CBR] [2]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Jindal S., Yang L., Day PJ., Kell DB., 2019, Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli., BMC Microbiol 19(1):195

 [2] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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