RegulonDB RegulonDB 11.1: Gene Form
   

ltaE gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

poxB ybjT ltaE anti-anti-terminator anti-terminator terminator ltaEp ltaEp ybjSp3 ybjSp3

Gene      
Name: ltaE    Texpresso search in the literature
Synonym(s): ECK0861, G6455, b0870, ltaA, ybjU
Genome position(nucleotides): 908293 <-- 909294
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 56.19
External database links:  
ASAP:
 ABE-0002954
ECHOBASE:
 EB3454
ECOLIHUB:
 ltaE
OU-MICROARRAY:
 b0870
STRING:
 511145.b0870
COLOMBOS: ltaE


Product      
Name: low-specificity L-threonine aldolase
Synonym(s): LtaA, LtaE, YbjU
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 36.495
Isoelectric point: 6.109
Motif(s):
 
Type Positions Sequence Comment
3 -> 282 DLRSDTVTRPSRAMLEAMMAAPVGDDVYGDDPTVNALQDYAAELSGKEAAIFLPTGTQANLVALLSHCERGEEYIVGQAAHNYLFEAGGAAVLGSIQPQPIDAAADGTLPLDKVAMKIKPDDIHFARTKLLSLENTHNGKVLPREYLKEAWEFTRERNLALHVDGARIFNAVVAYGCELKEITQYCDSFTICLSKGLGTPVGSLLVGNRDYIKRAIRWRKMTGGGMRQSGILAAAGIYALKNNVARLQEDHDNAAWMAEQLREAGADVMRQDTNMLFVRV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.5 - biosynthesis of building blocks --> 1.5.1 - amino acids --> 1.5.1.10 - glycine
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0003824 - catalytic activity
GO:0016829 - lyase activity
GO:0004793 - threonine aldolase activity
GO:0008732 - L-allo-threonine aldolase activity
GO:0050179 - phenylserine aldolase activity
GO:0030170 - pyridoxal phosphate binding
GO:0042802 - identical protein binding
biological_process GO:0006520 - cellular amino acid metabolic process
GO:0006545 - glycine biosynthetic process
GO:0006567 - threonine catabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Remesh SG., et al., 2015
[2] di Salvo ML., et al., 2014
External database links:  
ALPHAFOLD:
 P75823
ECOCYC:
 LTAA-MONOMER
ECOLIWIKI:
 b0870
INTERPRO:
 IPR015422
INTERPRO:
 IPR023603
INTERPRO:
 IPR015424
INTERPRO:
 IPR015421
INTERPRO:
 IPR001597
MINT:
 P75823
MODBASE:
 P75823
PANTHER:
 PTHR48097:SF9
PDB:
 3WLX
PFAM:
 PF01212
PRIDE:
 P75823
PRODB:
 PRO_000023135
REFSEQ:
 NP_415391
SMR:
 P75823
SWISSMODEL:
 P75823
UNIPROT:
 P75823


Operon      
Name: hcp-hcr-poxB-ltaE-ybjT         
Operon arrangement:
Transcription unit        Promoter
ltaE-ybjT
poxB
poxB
hcp-hcr
hcp-hcr-poxB
hcp-hcr
poxB-ltaE-ybjT


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter ybjSp3 906898 reverse nd [COMP-AINF] [3]


Evidence    

 [COMP-AINF] Inferred computationally without human oversight


Reference(s)    

 [1] Remesh SG., Ghatge MS., Ahmed MH., Musayev FN., Gandhi A., Chowdhury N., di Salvo ML., Kellogg GE., Contestabile R., Schirch V., Safo MK., 2015, Molecular basis of E. coli L-threonine aldolase catalytic inactivation at low pH., Biochim Biophys Acta 1854(4):278-83

 [2] di Salvo ML., Remesh SG., Vivoli M., Ghatge MS., Paiardini A., D'Aguanno S., Safo MK., Contestabile R., 2014, On the catalytic mechanism and stereospecificity of Escherichia coli l-threonine aldolase., FEBS J 281(1):129-45

 [3] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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