RegulonDB RegulonDB 10.9: Gene Form
   

clpS gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

clpA clpS yljB MqsA CRP CRP PhoP terminator TSS_1052 TSS_1052 TSS_1051 TSS_1051 TSS_1050 TSS_1050 TSS_1049 TSS_1049 TSS_1048 TSS_1048 TSS_1047 TSS_1047 TSS_1046 TSS_1046 TSS_1045 TSS_1045 TSS_1044 TSS_1044 TSS_1043 (cluster) TSS_1043 (cluster) TSS_1042 (cluster) TSS_1042 (cluster) TSS_1041 TSS_1041 TSS_1040 TSS_1040 TSS_1039 TSS_1039 TSS_1038 TSS_1038 clpAp3 clpAp3 clpAp2 clpAp2 TSS_1037 TSS_1037 clpAp1 clpAp1 TSS_1036 TSS_1036 TSS_1035 (cluster) TSS_1035 (cluster) TSS_1034 (cluster) TSS_1034 (cluster) TSS_1033 (cluster) TSS_1033 (cluster) clpSp7 clpSp7 TSS_1032 TSS_1032 TSS_1031 (cluster) TSS_1031 (cluster) TSS_1030 TSS_1030 clpSp clpSp clpSp6 clpSp6

Gene      
Name: clpS    Texpresso search in the literature
Synonym(s): ECK0872, G6463, b0881, yljA
Genome position(nucleotides): 922913 --> 923233 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
45.17
External database links:  
ASAP:
ABE-0002998
ECHOBASE:
EB3992
ECOLIHUB:
clpS
OU-MICROARRAY:
b0881
STRING:
511145.b0881
COLOMBOS: clpS


Product      
Name: specificity factor for ClpA-ClpP chaperone-protease complex
Synonym(s): ClpS, YljA
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 12.179
Isoelectric point: 4.685
Motif(s):
 
Type Positions Sequence
23 -> 102 KPPSMYKVILVNDDYTPMEFVIDVLQKFFSYDVERATQLMLAVHYQGKAICGVFTAEVAETKVAMVNKYARENEHPLLCT

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.2 - degradation of macromolecules --> 1.2.3 - proteins/peptides/glycopeptides
  2 - information transfer --> 2.3 - protein related --> 2.3.6 - turnover, degradation
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0005515 - protein binding
GO:0051087 - chaperone binding
biological_process GO:0006508 - proteolysis
GO:0009408 - response to heat
GO:0030163 - protein catabolic process
Note(s): Note(s): ...[more].
Evidence: [APPH] Assay of protein purified to homogeneity
Reference(s): [1] Dougan DA., et al., 2002
External database links:  
DIP:
DIP-35408N
ECOCYC:
G6463-MONOMER
ECOLIWIKI:
b0881
INTERPRO:
IPR022935
INTERPRO:
IPR014719
INTERPRO:
IPR003769
MINT:
P0A8Q6
MODBASE:
P0A8Q6
PDB:
2WA9
PDB:
3O1F
PDB:
3O2B
PDB:
3O2H
PDB:
3O2O
PDB:
2WA8
PDB:
2W9R
PDB:
1R6Q
PDB:
1R6O
PDB:
1MG9
PDB:
1MBX
PDB:
1MBV
PDB:
1MBU
PDB:
1LZW
PFAM:
PF02617
PRIDE:
P0A8Q6
PRODB:
PRO_000022299
REFSEQ:
NP_415402
SMR:
P0A8Q6
UNIPROT:
P0A8Q6


Operon      
Name: clpS         
Operon arrangement:
Transcription unit        Promoter
clpS


Transcriptional Regulation      
Display Regulation             
Repressed by: PhoP


RNA cis-regulatory element    
Attenuation: Translational


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter clpSp6 922750 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_1030 922827 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1031 (cluster) 922831 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_1032 922847 forward nd [RS-EPT-CBR] [3]
  promoter clpSp7 922912 forward Similarity to the consensus
Read more >
[ICWHO] [2]
  promoter TSS_1033 (cluster) 923059 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_1034 (cluster) 923062 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_1035 (cluster) 923067 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_1036 923070 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1037 923091 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1038 923211 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1039 923214 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1040 923248 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1041 923326 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1042 (cluster) 923332 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_1043 (cluster) 923775 forward For this promoter, there
Read more >
[RS-EPT-CBR] [3]
  promoter TSS_1044 923778 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1045 923930 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1046 924209 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1047 924234 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1048 924327 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1049 924428 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1050 924863 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1051 925036 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1052 925048 forward nd [RS-EPT-CBR] [3]


Evidence    

 [ICWHO] Inferred computationally without human oversight

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Dougan DA., Reid BG., Horwich AL., Bukau B., 2002, ClpS, a substrate modulator of the ClpAP machine., Mol Cell 9(3):673-83

 [2] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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