RegulonDB RegulonDB 10.9: Gene Form
   

mgsA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

helD yccT mgsA anti-anti-terminator anti-terminator terminator mgsAp mgsAp TSS_1288 TSS_1288 TSS_1287 TSS_1287

Gene      
Name: mgsA    Texpresso search in the literature
Synonym(s): ECK0954, G6497, b0963, mgs, yccG
Genome position(nucleotides): 1026557 <-- 1027015 Genome Browser
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
52.72
External database links:  
ASAP:
ABE-0003259
ECHOBASE:
EB2213
ECOLIHUB:
mgsA
OU-MICROARRAY:
b0963
STRING:
511145.b0963
COLOMBOS: mgsA


Product      
Name: methylglyoxal synthase
Synonym(s): Mgs, MgsA, YccG
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 16.919
Isoelectric point: 6.634
Motif(s):
 
Type Positions Sequence
45 -> 48 TGTT
98 -> 98 H
65 -> 66 SG
71 -> 71 D
1 -> 2 ME

 

Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.7 - central intermediary metabolism --> 1.7.23 - methylglyoxal metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
molecular_function GO:0016829 - lyase activity
GO:0008929 - methylglyoxal synthase activity
GO:0042802 - identical protein binding
biological_process GO:0019242 - methylglyoxal biosynthetic process
GO:0034214 - protein hexamerization
External database links:  
DIP:
DIP-48252N
ECOCYC:
METHGLYSYN-MONOMER
ECOLIWIKI:
b0963
INTERPRO:
IPR036914
INTERPRO:
IPR018148
INTERPRO:
IPR011607
INTERPRO:
IPR004363
MODBASE:
P0A731
PANTHER:
PTHR30492
PDB:
1IK4
PDB:
1S8A
PDB:
1S89
PDB:
1EGH
PDB:
1B93
PFAM:
PF02142
PRIDE:
P0A731
PRODB:
PRO_000023226
PROSITE:
PS01335
PROSITE:
PS51855
REFSEQ:
NP_415483
SMART:
SM00851
SMR:
P0A731
UNIPROT:
P0A731


Operon      
Name: mgsA         
Operon arrangement:
Transcription unit        Promoter
mgsA


RNA cis-regulatory element    
Attenuation: Transcriptional


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1287 1025511 forward nd [RS-EPT-CBR] [1]
  promoter TSS_1288 1027030 reverse nd [RS-EPT-CBR] [1]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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