RegulonDB RegulonDB 11.1: Gene Form
   

rutA gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

rutA rutB rutR rutC NtrC NtrC PhoP RutR ArcA terminator anti-terminator anti-anti-terminator rutRp1 rutRp1 rutRp2 rutRp2 rutAp rutAp

Gene      
Name: rutA    Texpresso search in the literature
Synonym(s): ECK1003, G6523, b1012, ycdM
Genome position(nucleotides): 1072863 <-- 1074011
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 55.09
External database links:  
ASAP:
 ABE-0003416
ECHOBASE:
 EB3619
ECOLIHUB:
 rutA
OU-MICROARRAY:
 b1012
STRING:
 511145.b1012
COLOMBOS: rutA


Product      
Name: pyrimidine monooxygenase RutA
Synonym(s): RutA, YcdM, pyrimidine oxygenase
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 42.219
Isoelectric point: 4.889
Motif(s):
 
Type Positions Sequence Comment
20 -> 339 MKIGVFVPIGNNGWLISTHAPQYMPTFELNKAIVQKAEHYHFDFALSMIKLRGFGGKTEFWDHNLESFTLMAGLAAVTSRIQIYATAATLTLPPAIVARMAATIDSISGGRFGVNLVTGWQKPEYEQMGIWPGDDYFSRRYDYLTEYVQVLRDLWGTGKSDFKGDFFTMNDCRVSPQPSVPMKVICAGQSDAGMAFSARYADFNFCFGKGVNTPTAFAPTAARMKQAAEQTGRDVGSYVLFMVIADETDDAARAKWEHYKAGADEEALSWLTEQSQKDTRSGTDTNVRQMADPTSAVNINMGTLVGSYASVARMLDEVAS
68 -> 69 IK UniProt: FMN.
159 -> 160 RY UniProt: FMN.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.3 - nitrogen metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
molecular_function GO:0016491 - oxidoreductase activity
GO:0004497 - monooxygenase activity
GO:0008726 - alkanesulfonate monooxygenase activity
GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0052614 - uracil oxygenase activity
biological_process GO:0006208 - pyrimidine nucleobase catabolic process
GO:0019740 - nitrogen utilization
GO:0046306 - alkanesulfonate catabolic process
GO:0006212 - uracil catabolic process
GO:0006210 - thymine catabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Adak S., et al., 2019
External database links:  
ALPHAFOLD:
 P75898
ECOCYC:
 G6523-MONOMER
ECOLIWIKI:
 b1012
INTERPRO:
 IPR019914
INTERPRO:
 IPR036661
INTERPRO:
 IPR011251
MODBASE:
 P75898
PDB:
 6TEG
PDB:
 6SGL
PDB:
 6TEF
PDB:
 6SGG
PDB:
 6SGN
PDB:
 6TEE
PDB:
 5WAN
PDB:
 6SGM
PFAM:
 PF00296
PRIDE:
 P75898
REFSEQ:
 NP_415532
SMR:
 P75898
UNIPROT:
 P75898


Operon      
Name: rutABCDEFG         
Operon arrangement:
Transcription unit        Promoter
rutABCDEFG


Transcriptional Regulation      
Display Regulation             
Activated by: PhoP, NtrC, ArcA
Repressed by: RutR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Adak S., Begley TP., 2019, Flavin-N5-oxide intermediates in dibenzothiophene, uracil, and hexachlorobenzene catabolism., Methods Enzymol 620:455-468

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