RegulonDB RegulonDB 11.1: Gene Form
   

opgC gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

opgG clsC opgC opgH TSS_1329 (cluster) TSS_1329 (cluster) TSS_1328 TSS_1328 opgGp1 opgGp1 opgGp2 opgGp2 opgGp opgGp

Gene      
Name: opgC    Texpresso search in the literature
Synonym(s): ECK1033, G6552, b1047, mdoC, ymdD
Genome position(nucleotides): 1107784 <-- 1108941
Strand: reverse
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 43.87
External database links:  
ASAP:
 ABE-0003553
ECHOBASE:
 EB3635
ECOLIHUB:
 mdoC
OU-MICROARRAY:
 b1047
STRING:
 511145.b1047
COLOMBOS: opgC


Product      
Name: osmoregulated periplasmic glucans (OPG) biosynthesis protein C
Synonym(s): MdoC, O-succinyl transferase, OpgC, YmdD
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 44.69
Isoelectric point: 10.131
Motif(s):
 
Type Positions Sequence Comment
10 -> 356 YFLDSIRAWLMLLGIPFHISLIYSSHTWHVNSAESSLWLTLFNDFIHSFRMQVFFVISGYFSYMLFLRYPLKKWWKVRVERVGIPMLTAIPLLTLPQFIMLQYVKGKAESWPGLSLYDKYNTLAWELISHLWFLLVLVVMTTLCVWIFKRIRNNLENSDKTNKKFSMVKLSVIFLCLGIGYAVIRRTIFIVYPPILSNGMFNFIVMQTLFYLPFFILGALAFIFPHLKALFTTPSRGCTLAAALAFVAYLLNQRYGSGDAWMYETESVITMVLGLWMVNVVFSFGHRLLNFQSARVTYFVNASLFIYLVHHPLTLFFGAYITPHITSNWLGFLCGLIFVVGIAIILY
17 -> 37 AWLMLLGIPFHISLIYSSHTW UniProt: Helical.
60 -> 80 MQVFFVISGYFSYMLFLRYPL UniProt: Helical.
91 -> 111 VGIPMLTAIPLLTLPQFIMLQ UniProt: Helical.
137 -> 157 ISHLWFLLVLVVMTTLCVWIF UniProt: Helical.

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.6 - biosynthesis of macromolecules (cellular constituents) --> 1.6.6 - osmoregulated periplasmic glucan
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:0016741 - transferase activity, transferring one-carbon groups
GO:0016740 - transferase activity
GO:0016746 - acyltransferase activity
GO:0016747 - acyltransferase activity, transferring groups other than amino-acyl groups
GO:0016748 - succinyltransferase activity
biological_process GO:0009250 - glucan biosynthetic process
GO:1900727 - osmoregulated periplasmic glucan biosynthetic process
Note(s): Note(s): ...[more].
Evidence: [EXP-IMP] Inferred from mutant phenotype
Reference(s): [1] Cogez V., et al., 2002
[2] Lacroix JM., et al., 1999
External database links:  
ALPHAFOLD:
 P75920
ECOCYC:
 G6552-MONOMER
ECOLIWIKI:
 b1047
INTERPRO:
 IPR023723
INTERPRO:
 IPR002656
PFAM:
 PF01757
PRIDE:
 P75920
PRODB:
 PRO_000023178
REFSEQ:
 NP_415565
UNIPROT:
 P75920


Operon      
Name: opgC         
Operon arrangement:
Transcription unit        Promoter
mdoC


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1328 1110128 forward nd [RS-EPT-CBR] [3]
  promoter TSS_1329 (cluster) 1110416 forward nd [RS-EPT-CBR] [3]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates


Reference(s)    

 [1] Cogez V., Gak E., Puskas A., Kaplan S., Bohin JP., 2002, The opgGIH and opgC genes of Rhodobacter sphaeroides form an operon that controls backbone synthesis and succinylation of osmoregulated periplasmic glucans., Eur J Biochem 269(10):2473-84

 [2] Lacroix JM., Lanfroy E., Cogez V., Lequette Y., Bohin A., Bohin JP., 1999, The mdoC gene of Escherichia coli encodes a membrane protein that is required for succinylation of osmoregulated periplasmic glucans., J Bacteriol 181(12):3626-31

 [3] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.

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