RegulonDB RegulonDB 10.9: Gene Form
   

murJ gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

murJ yceM flgN TSS_1341 TSS_1341

Gene      
Name: murJ    Texpresso search in the literature
Synonym(s): ECK1054, G6561, b1069, mviN, yceN
Genome position(nucleotides): 1127839 --> 1129374 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
53.71
External database links:  
ASAP:
ABE-0003630
ECHOBASE:
EB3639
ECOLIHUB:
murJ
OU-MICROARRAY:
b1069
STRING:
511145.b1069
COLOMBOS: murJ


Product      
Name: lipid II flippase MurJ
Synonym(s): MurJ, MviN, YceN
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane
Molecular weight: 55.268
Isoelectric point: 10.628
Motif(s):
 
Type Positions Sequence
18 -> 18 R
409 -> 429 GLSLSIGLAACLNASLLYWQL
6 -> 32 SLAAVSSMTMFSRVLGFARDAIVARIF
39 -> 39 D
52 -> 52 R

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.2 - Electrochemical potential driven transporters --> 4.2.A - Porters (Uni-, Sym- and Antiporters)
  6 - cell structure --> 6.1 - membrane
Gene Ontology Terms (GO)  
cellular_component GO:0000935 - division septum
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0005887 - integral component of plasma membrane
GO:0016021 - integral component of membrane
molecular_function GO:1901612 - cardiolipin binding
GO:0015648 - lipid-linked peptidoglycan transporter activity
biological_process GO:0009252 - peptidoglycan biosynthetic process
GO:0008360 - regulation of cell shape
GO:0034204 - lipid translocation
GO:0071555 - cell wall organization
GO:0015836 - lipid-linked peptidoglycan transport
GO:0034203 - glycolipid translocation
Note(s): Note(s): ...[more].
Reference(s): [1] Afset JE., et al., 2006
[2] Bruant G., et al., 2006
[3] Elhenawy W., et al., 2016
[4] Lerat E., et al., 2003
[5] MacLeod D., et al., 2005
[6] Price MN., et al., 2005
External database links:  
ECOCYC:
G6561-MONOMER
ECOLIWIKI:
b1069
INTERPRO:
IPR004268
PDB:
6CC4
PFAM:
PF03023
PRIDE:
P0AF16
PRINTS:
PR01806
PRODB:
PRO_000023330
REFSEQ:
NP_415587
SMR:
P0AF16
UNIPROT:
P0AF16


Operon      
Name: murJ         
Operon arrangement:
Transcription unit        Promoter
murJ


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter TSS_1341 1127783 forward nd [RS-EPT-CBR] [7]


Evidence    

 [RS-EPT-CBR] RNA-seq using two enrichment strategies for primary transcripts and consistent biological replicates



Reference(s)    

 [1] Afset JE., Bruant G., Brousseau R., Harel J., Anderssen E., Bevanger L., Bergh K., 2006, Identification of virulence genes linked with diarrhea due to atypical enteropathogenic Escherichia coli by DNA microarray analysis and PCR., J Clin Microbiol 44(10):3703-11

 [2] Bruant G., Maynard C., Bekal S., Gaucher I., Masson L., Brousseau R., Harel J., 2006, Development and validation of an oligonucleotide microarray for detection of multiple virulence and antimicrobial resistance genes in Escherichia coli., Appl Environ Microbiol 72(5):3780-4

 [3] Elhenawy W., Davis RM., Fero J., Salama NR., Felman MF., Ruiz N., 2016, The O-Antigen Flippase Wzk Can Substitute for MurJ in Peptidoglycan Synthesis in Helicobacter pylori and Escherichia coli., PLoS One 11(8):e0161587

 [4] Lerat E., Daubin V., Moran NA., 2003, From gene trees to organismal phylogeny in prokaryotes: the case of the gamma-Proteobacteria., PLoS Biol 1(1):E19

 [5] MacLeod D., Charlebois RL., Doolittle F., Bapteste E., 2005, Deduction of probable events of lateral gene transfer through comparison of phylogenetic trees by recursive consolidation and rearrangement., BMC Evol Biol 5(1):27

 [6] Price MN., Huang KH., Arkin AP., Alm EJ., 2005, Operon formation is driven by co-regulation and not by horizontal gene transfer., Genome Res 15(6):809-19

 [7] Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muñiz-Rascado L, García-Sotelo JS, Weiss V, Solano-Lira H, Martínez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernández S, Alquicira-Hernández K, López-Fuentes A, Porrón-Sotelo L, Huerta AM, Bonavides-Martínez C, Balderas-Martínez YI, Pannier L, Olvera M, Labastida A, Jiménez-Jacinto V, Vega-Alvarado L, Del Moral-Chávez V, Hernández-Alvarez A, Morett E, Collado-Vides J., 2012, RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more., Nucleic Acids Res.


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