RegulonDB

Gene
Name:	iraM
Synonym(s):	ECK1147, G6600, b1160, elb1, elbA, ycgW
Genome position(nucleotides):	1211680 <-- 1212003 Genome Browser
Strand:	reverse
Sequence:	Get nucleotide sequence FastaFormat
GC content %:	33.95
External database links:

ASAP:	ABE-0003893
ECHOBASE:	EB3644
ECOLIHUB:	iraM
OU-MICROARRAY:	b1160
STRING:	511145.b1160
COLOMBOS:	iraM

Product

Name:

anti-adaptor protein IraM

Synonym(s):

ElbA, IraM, YcgW, anti-adaptor protein IraM, inhibitor of sigma;^S proteolysis

Sequence:

Get amino acid sequence Fasta Format

Cellular location:

cytosol

Molecular weight:

12.133

Isoelectric point:

9.004

Classification:

Multifun Terms (GenProtEC)
		3 - regulation --> 3.1 - type of regulation --> 3.1.3 - posttranscriptional
		5 - cell processes --> 5.5 - adaptations --> 5.5.3 - starvation
Gene Ontology Terms (GO)
	cellular_component	GO:0005737 - cytoplasm
	molecular_function	GO:0005515 - protein binding GO:0043856 - anti-sigma factor antagonist activity
	biological_process	GO:0045893 - positive regulation of transcription, DNA-templated GO:0009267 - cellular response to starvation GO:0010350 - cellular response to magnesium starvation GO:0042177 - negative regulation of protein catabolic process GO:0071468 - cellular response to acidic pH

Note(s):

Note(s): ...[more].

Evidence:

[IDA] Inferred from direct assay

Reference(s):

[1] Bougdour A., et al., 2008
[2] Svanberg Frisinger F., et al., 2021

External database links:

ECOCYC:

ECOLIWIKI:

INTERPRO:

PRIDE:

PRODB:

REFSEQ:

UNIPROT:

Operon

Name:

iraM

Operon arrangement:

Transcriptional Regulation
	Display Regulation
Activated by:	PhoP, FNR, ArcA

Elements in the selected gene context region unrelated to any object in RegulonDB

	Type	Name	Post Left	Post Right	Strand	Notes	Evidence (Confirmed, Strong, Weak)	References

Reference(s)
[1] Bougdour A., Cunning C., Baptiste PJ., Elliott T., Gottesman S., 2008, Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors., Mol Microbiol 68(2):298-313
[2] Svanberg Frisinger F., Jana B., Donadio S., Guardabassi L., 2021, In Silico Prediction and Prioritization of Novel Selective Antimicrobial Drug Targets in Escherichia coli., Antibiotics (Basel) 10(6)