RegulonDB RegulonDB 10.10: Gene Form
   

patD gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

patD ydcV yncL ydcU patDp4 patDp4 patDp3 patDp3

Gene      
Name: patD    Texpresso search in the literature
Synonym(s): ECK1438, G6755, b1444, prr, ydcW
Genome position(nucleotides): 1515578 --> 1517002 Genome Browser
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
 53.19
External database links:  
ASAP:
 ABE-0004813
ECHOBASE:
 EB3529
ECOLIHUB:
 ydcW
OU-MICROARRAY:
 b1444
STRING:
 511145.b1444
COLOMBOS: patD


Product      
Name: γ-aminobutyraldehyde dehydrogenase
Synonym(s): PatD, Prr, YdcW
Sequence: Get amino acid sequence Fasta Format
Cellular location: cytosol
Molecular weight: 50.83
Isoelectric point: 5.893
Motif(s):
 
Type Positions Sequence
172 -> 175 KPSE
146 -> 148 APW
225 -> 231 SIATGEH
13 -> 470 SGEGEKQPVYNPATGDVLLEIAEASAEQVDAAVRAADAAFAEWGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGAARCLNGLAAGEYLEGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFPAGVINILFGRGKTVGDPLTGHPKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCTWVNTHFMLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHV

 
Classification:
Multifun Terms (GenProtEC)  
  1 - metabolism --> 1.8 - metabolism of other compounds --> 1.8.3 - nitrogen metabolism
Gene Ontology Terms (GO)  
cellular_component GO:0005829 - cytosol
GO:0032991 - protein-containing complex
molecular_function GO:0016491 - oxidoreductase activity
GO:0016620 - oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0019145 - aminobutyraldehyde dehydrogenase activity
GO:0042802 - identical protein binding
GO:0051287 - NAD binding
GO:0004029 - aldehyde dehydrogenase (NAD+) activity
GO:0033737 - 1-pyrroline dehydrogenase activity
biological_process GO:0009447 - putrescine catabolic process
GO:0051289 - protein homotetramerization
GO:0019477 - L-lysine catabolic process
Note(s): Note(s): ...[more].
Reference(s): [1] Jorge JM., et al., 2016
[2] Jorge JM., et al., 2017
[3] Knorr S., et al., 2018
[4] Perez-Garcia F., et al., 2018
External database links:  
DIP:
 DIP-11656N
ECOCYC:
 G6755-MONOMER
ECOLIWIKI:
 b1444
ECOO157CYC:
 Z2275-MONOMER
INTERPRO:
 IPR016163
INTERPRO:
 IPR017749
INTERPRO:
 IPR016162
INTERPRO:
 IPR016161
INTERPRO:
 IPR015657
INTERPRO:
 IPR015590
INTERPRO:
 IPR029510
MODBASE:
 P77674
PANTHER:
 PTHR11699:SF109
PDB:
 1WNB
PDB:
 1WND
PFAM:
 PF00171
PRIDE:
 P77674
PROSITE:
 PS00687
REFSEQ:
 NP_415961
SMR:
 P77674
UNIPROT:
 P77674


Operon      
Name: ydcSTUV-patD         
Operon arrangement:
Transcription unit        Promoter
ydcSTUV-patD
patD
ydcSTUV-patD


Transcriptional Regulation      
Display Regulation             
Activated by: Nac


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References
  promoter patDp3 1515415 forward nd [ICWHO] [5]
  promoter patDp4 1515440 forward nd [ICWHO] [5]


Evidence    

 [ICWHO] Inferred computationally without human oversight


Reference(s)    

 [1] Jorge JM., Leggewie C., Wendisch VF., 2016, A new metabolic route for the production of gamma-aminobutyric acid by Corynebacterium glutamicum from glucose., Amino Acids 48(11):2519-2531

 [2] Jorge JM., Nguyen AQ., Perez-Garcia F., Kind S., Wendisch VF., 2017, Improved fermentative production of gamma-aminobutyric acid via the putrescine route: Systems metabolic engineering for production from glucose, amino sugars, and xylose., Biotechnol Bioeng 114(4):862-873

 [3] Knorr S., Sinn M., Galetskiy D., Williams RM., Wang C., Muller N., Mayans O., Schleheck D., Hartig JS., 2018, Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate., Nat Commun 9(1):5071

 [4] Perez-Garcia F., Jorge JMP., Dreyszas A., Risse JM., Wendisch VF., 2018, Efficient Production of the Dicarboxylic Acid Glutarate by Corynebacterium glutamicum via a Novel Synthetic Pathway., Front Microbiol 9:2589

 [5] Huerta AM., Collado-Vides J., 2003, Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals., J Mol Biol 333(2):261-78

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