RegulonDB RegulonDB 11.0: Gene Form
   

lsrB gene in Escherichia coli K-12 genome


Gene local context to scale (view description)

lsrB lsrD lsrF

Gene      
Name: lsrB    Texpresso search in the literature
Synonym(s): ECK1509, G6803, b1516, yneA
Genome position(nucleotides): 1605051 --> 1606073
Strand: forward
Sequence: Get nucleotide sequence FastaFormat
GC content %:  
49.66
External database links:  
ASAP:
ABE-0005063
ECHOBASE:
EB3570
ECOLIHUB:
lsrB
OU-MICROARRAY:
b1516
STRING:
511145.b1516
COLOMBOS: lsrB


Product      
Name: Autoinducer-2 ABC transporter periplasmic binding protein
Synonym(s): LsrB, YneA
Sequence: Get amino acid sequence Fasta Format
Cellular location: inner membrane,periplasmic space
Molecular weight: 36.685
Isoelectric point: 8.141
Motif(s):
 
Type Positions Sequence Comment
1 -> 26 MTLHRFKKIALLSALGIAAISMNVQA
27 -> 340 AERIAFIPKLVGVGFFTSGGNGAQQAGKELGVDVTYDGPTEPSVSGQVQLINNFVNQGYNAIIVSAVSPDGLCPALKRAMQRGVRVLTWDSDTKPECRSYYINQGTPAQLGGMLVDMAARQVNKDKAKVAFFYSSPTVTDQNQWVKEAKAKIAKEHPGWEIVTTQFGYNDATKSLQTAEGILKAYSDLDAIIAPDANALPAAAQAAENLKNDKVAIVGFSTPNVMRPYVERGTVKEFGLWDVVQQGKISVYVADALLKKGSMKTGDKLDIKGVGQVEVSPNSVQGYDYEADGNGIVLLPERVIFNKENIGKYDF UniProt: Autoinducer 2-binding protein LsrB.
30 -> 285 IAFIPKLVGVGFFTSGGNGAQQAGKELGVDVTYDGPTEPSVSGQVQLINNFVNQGYNAIIVSAVSPDGLCPALKRAMQRGVRVLTWDSDTKPECRSYYINQGTPAQLGGMLVDMAARQVNKDKAKVAFFYSSPTVTDQNQWVKEAKAKIAKEHPGWEIVTTQFGYNDATKSLQTAEGILKAYSDLDAIIAPDANALPAAAQAAENLKNDKVAIVGFSTPNVMRPYVERGTVKEFGLWDVVQQGKISVYVADALLKK

 

Classification:
Multifun Terms (GenProtEC)  
  4 - transport --> 4.3 - Primary Active Transporters --> 4.3.A - Pyrophosphate Bond (ATP; GTP; P2) Hydrolysis-driven Active Transporters --> 4.3.A.1 - The ATP-binding Cassette (ABC) Superfamily + ABC-type Uptake Permeases --> 4.3.A.1.p - ABC superfamily, periplasmic binding component
Gene Ontology Terms (GO)  
cellular_component GO:0016020 - membrane
GO:0030288 - outer membrane-bounded periplasmic space
GO:0042597 - periplasmic space
GO:0043190 - ATP-binding cassette (ABC) transporter complex
GO:0055052 - ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
biological_process GO:1905887 - autoinducer AI-2 transmembrane transport
GO:0009372 - quorum sensing
Note(s): Note(s): ...[more].
Reference(s): [1] Ding Y., et al., 2021
[2] Li X., et al., 2021
External database links:  
ALPHAFOLD:
P76142
ECOCYC:
YNEA-MONOMER
ECOLIWIKI:
b1516
INTERPRO:
IPR028082
INTERPRO:
IPR025997
INTERPRO:
IPR030159
MODBASE:
P76142
PANTHER:
PTHR46847:SF4
PFAM:
PF13407
PRIDE:
P76142
PRODB:
PRO_000023129
REFSEQ:
NP_416033
SMR:
P76142
SWISSMODEL:
P76142
UNIPROT:
P76142


Operon      
Name: lsrACDBFG-tam         
Operon arrangement:
Transcription unit        Promoter
lsrACDBFG-tam
tam


Transcriptional Regulation      
Display Regulation             
Activated by: CRP
Repressed by: LsrR


Elements in the selected gene context region unrelated to any object in RegulonDB      

  Type Name Post Left Post Right Strand Notes Evidence (Confirmed, Strong, Weak) References


Reference(s)    

 [1] Ding Y., Zhang D., Zhao X., Tan W., Zheng X., Zhang Q., Ji X., Wei Y., 2021, Autoinducer-2-mediated quorum-sensing system resists T4 phage infection in Escherichia coli., J Basic Microbiol 61(12):1113-1123

 [2] Li X., Chen L., Zhou H., Gu S., Wu Y., Wang B., Zhang M., Ding N., Sun J., Pang X., Lu D., 2021, LsrB, the hub of ABC transporters involved in the membrane damage mechanisms of heavy ion irradiation in Escherichia coli., Int J Radiat Biol 97(12):1731-1740


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